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GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity

Term Information

ID GO:0045736
Name negative regulation of cyclin-dependent protein serine/threonine kinase activity
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
GONUTS GO:0045736 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact downregulation of cyclin-dependent protein kinase activity
exact down-regulation of cyclin-dependent protein kinase activity
exact down regulation of cyclin-dependent protein kinase activity
related cyclin-dependent kinase inhibitor
related CDK inhibitor
broad negative regulation of cyclin-dependent protein kinase activity
narrow inhibition of cyclin-dependent protein kinase activity
exact negative regulation of CDK activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
cell cycleLink

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0045736:
Relationship To GO:0045736 Child Term Child Term Name
Is a GO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
Is a GO:0031661 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0045736. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0045736 based on the entire annotation set Co-occurrence statistics for GO:0045736 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-03-08 Added SYNONYM negative regulation of cyclin-dependent protein kinase activity
2013-03-08 Updated TERM negative regulation of cyclin-dependent protein serine/threonine kinase activity
2013-03-08 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity.
2013-03-08 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2010-09-17 Added RELATION is a GO:0071901 (negative regulation of protein serine/threonine kinase activity)
2010-09-17 Deleted RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2010-06-15 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2010-06-08 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2009-02-22 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2008-04-01 Updated RELATION is a GO:0045786 (negative regulation of cell cycle)
2008-04-01 Updated RELATION is a GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
2008-04-01 Updated RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2007-08-09 Added SYNONYM CDK inhibitor
2007-08-09 Added SYNONYM cyclin-dependent kinase inhibitor
2007-08-09 Added SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM inhibition of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM negative regulation of CDK activity
2007-08-09 Deleted SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM inhibition of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM CDK inhibitor
2007-08-09 Deleted SYNONYM cyclin-dependent kinase inhibitor
2007-08-09 Deleted SYNONYM negative regulation of CDK activity
2007-02-23 Added SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM inhibition of cyclin-dependent protein kinase activity
2006-08-13 Deleted SYNONYM cyclin dependent kinase inhibitor
2006-08-13 Added SYNONYM cyclin-dependent kinase inhibitor
2006-08-06 Updated TERM negative regulation of cyclin-dependent protein kinase activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of CDK activity.
2004-07-08 Added SYNONYM CDK inhibitor
2004-07-08 Added SYNONYM cyclin dependent kinase inhibitor
2004-07-04 Deleted SYNONYM CDK inhibitor
2004-07-04 Deleted SYNONYM cyclin dependent kinase inhibitor
2004-07-02 Added SYNONYM CDK inhibitor
2004-07-02 Added SYNONYM cyclin dependent kinase inhibitor
2004-04-19 Added SYNONYM negative regulation of CDK activity
2004-04-16 Deleted SYNONYM negative regulation of CDK activity
2004-03-13 Added SYNONYM negative regulation of CDK activity
2004-03-13 Updated TERM negative regulation of cyclin dependent protein kinase activity
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of CDK activity.
2002-08-20 Added TERM negative regulation of CDK activity

Term

Timestamp Action Category Detail
2013-03-08 Updated TERM negative regulation of cyclin-dependent protein serine/threonine kinase activity
2006-08-06 Updated TERM negative regulation of cyclin-dependent protein kinase activity
2004-03-13 Updated TERM negative regulation of cyclin dependent protein kinase activity
2002-08-20 Added TERM negative regulation of CDK activity

Definition/synonyms

Timestamp Action Category Detail
2013-03-08 Added SYNONYM negative regulation of cyclin-dependent protein kinase activity
2013-03-08 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity.
2013-03-08 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of CDK activity.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2007-08-09 Added SYNONYM CDK inhibitor
2007-08-09 Added SYNONYM cyclin-dependent kinase inhibitor
2007-08-09 Added SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM inhibition of cyclin-dependent protein kinase activity
2007-08-09 Added SYNONYM negative regulation of CDK activity
2007-08-09 Deleted SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM inhibition of cyclin-dependent protein kinase activity
2007-08-09 Deleted SYNONYM CDK inhibitor
2007-08-09 Deleted SYNONYM cyclin-dependent kinase inhibitor
2007-08-09 Deleted SYNONYM negative regulation of CDK activity
2007-02-23 Added SYNONYM down regulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM down-regulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM downregulation of cyclin-dependent protein kinase activity
2007-02-23 Added SYNONYM inhibition of cyclin-dependent protein kinase activity
2006-08-13 Deleted SYNONYM cyclin dependent kinase inhibitor
2006-08-13 Added SYNONYM cyclin-dependent kinase inhibitor
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of CDK activity.
2004-07-08 Added SYNONYM CDK inhibitor
2004-07-08 Added SYNONYM cyclin dependent kinase inhibitor
2004-07-04 Deleted SYNONYM CDK inhibitor
2004-07-04 Deleted SYNONYM cyclin dependent kinase inhibitor
2004-07-02 Added SYNONYM CDK inhibitor
2004-07-02 Added SYNONYM cyclin dependent kinase inhibitor
2004-04-19 Added SYNONYM negative regulation of CDK activity
2004-04-16 Deleted SYNONYM negative regulation of CDK activity
2004-03-13 Added SYNONYM negative regulation of CDK activity
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of CDK activity.

Relationships

Timestamp Action Category Detail
2010-09-17 Added RELATION is a GO:0071901 (negative regulation of protein serine/threonine kinase activity)
2010-09-17 Deleted RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2010-06-15 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2010-06-08 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2009-02-22 Added RELATION negatively regulates GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
2008-04-01 Updated RELATION is a GO:0045786 (negative regulation of cell cycle)
2008-04-01 Updated RELATION is a GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
2008-04-01 Updated RELATION is a GO:0006469 (negative regulation of protein kinase activity)
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