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GO:0045250 cytosolic pyruvate dehydrogenase complex

Term Information

ID GO:0045250
Name cytosolic pyruvate dehydrogenase complex
Ontology Cellular Component
Definition Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
Comment Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
GONUTS GO:0045250 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related pyruvate dehydrogenase complex (lipoamide)

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0045250:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0045250. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0045250 based on the entire annotation set Co-occurrence statistics for GO:0045250 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-07-25 Added RELATION is a GO:0044445 (cytosolic part)
2009-08-31 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2009-08-31 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2009-08-31 Added SYNONYM pyruvate dehydrogenase complex (lipoamide)
2008-05-13 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2008-05-12 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2008-04-01 Updated RELATION is a GO:0045254 (pyruvate dehydrogenase complex)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-02-16 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2007-02-12 Added SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-02-12 Updated TERM cytosolic pyruvate dehydrogenase complex
2007-01-18 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Bacteria research community)
2007-01-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-01-18 Updated TERM pyruvate dehydrogenase complex (sensu Bacteria)
2007-01-15 Updated TERM pyruvate dehydrogenase complex (sensu the Bacteria research community)
2007-01-15 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-01-15 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Bacteria research community)
2004-08-13 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2004-04-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2004-02-24 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Eubacteria (Bacteria, ncbi_taxonomy_id:2).
2003-04-24 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in bacteria; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2003-04-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2003-04-18 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in bacteria; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2002-05-10 Added TERM pyruvate dehydrogenase complex (sensu Bacteria)

Term

Timestamp Action Category Detail
2007-02-12 Updated TERM cytosolic pyruvate dehydrogenase complex
2007-01-18 Updated TERM pyruvate dehydrogenase complex (sensu Bacteria)
2007-01-15 Updated TERM pyruvate dehydrogenase complex (sensu the Bacteria research community)
2002-05-10 Added TERM pyruvate dehydrogenase complex (sensu Bacteria)

Definition/synonyms

Timestamp Action Category Detail
2009-08-31 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2009-08-31 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2009-08-31 Added SYNONYM pyruvate dehydrogenase complex (lipoamide)
2008-05-13 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2008-05-12 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-02-16 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2007-02-12 Added SYNONYM pyruvate dehydrogenase complex (sensu Bacteria)
2007-01-18 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Bacteria research community)
2007-01-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-01-15 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2007-01-15 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Bacteria research community)
2004-08-13 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2004-04-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2004-02-24 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Eubacteria (Bacteria, ncbi_taxonomy_id:2).
2003-04-24 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in bacteria; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
2003-04-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)
2003-04-18 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in bacteria; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.

Relationships

Timestamp Action Category Detail
2013-07-25 Added RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0045254 (pyruvate dehydrogenase complex)
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