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EBIDatabasesQuickGO

GO:0045190 isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

Term Information

ID GO:0045190
Name isotype switching
Ontology Biological Process
Definition The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.

Synonyms

Type Synonym
exact isotype switch recombination
exact class switching
exact class switch recombination

Cross-references associated with this term:

Database ID
Wikipedia Immunoglobulin_class_switching

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0002376 immune system process
GO:0032502 developmental process
GO:0032501 multicellular organismal process
GO:0050896 response to stimulus
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0048856 anatomical structure development
GO:0043170 macromolecule metabolic process
GO:0044238 primary metabolic process
GO:0001775 cell activation
GO:0007275 multicellular organismal development
GO:0006955 immune response
GO:0043283 biopolymer metabolic process
GO:0044237 cellular metabolic process
GO:0045321 leukocyte activation
GO:0002252 immune effector process
GO:0002250 adaptive immune response
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002440 production of molecular mediator of immune response
GO:0046649 lymphocyte activation
GO:0002443 leukocyte mediated immunity
GO:0044260 cellular macromolecule metabolic process
GO:0048731 system development
GO:0002377 immunoglobulin production
GO:0042113 B cell activation
GO:0002449 lymphocyte mediated immunity
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0034960 cellular biopolymer metabolic process
GO:0002520 immune system development
GO:0002200 somatic diversification of immune receptors
GO:0019724 B cell mediated immunity
GO:0016064 immunoglobulin mediated immune response
GO:0006259 DNA metabolic process
GO:0006310 DNA recombination
GO:0016444 somatic cell DNA recombination
GO:0002381 immunoglobulin production during immune response
GO:0016445 somatic diversification of immunoglobulins
GO:0002208 somatic diversification of immunoglobulins during immune response
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0002204 somatic recombination of immunoglobulin genes during immune response
GO:0045190 isotype switching

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0048289 isotype switching to IgE isotypes
I GO:0048290 isotype switching to IgA isotypes
I GO:0048291 isotype switching to IgG isotypes
I GO:0048292 isotype switching to IgD isotypes
NR GO:0045829 negative regulation of isotype switching
PR GO:0045830 positive regulation of isotype switching
R GO:0045191 regulation of isotype switching

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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17ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-11-23-04-03-36
Terminal
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