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GO:0045122 aflatoxin biosynthetic process

The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.

Term Information

ID GO:0045122
Name aflatoxin biosynthetic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Comment

Synonyms

Type Synonym
exact aflatoxin synthesis
exact aflatoxin formation
exact aflatoxin biosynthesis
exact aflatoxin anabolism

Cross-references associated with this term:

Database ID
INTERPRO IPR013700

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Ancestor Chart

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Ancestor Table

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0050896 response to stimulus
GO:0042221 response to chemical stimulus
GO:0009058 biosynthetic process
GO:0019748 secondary metabolic process
GO:0044238 primary metabolic process
GO:0009636 response to toxin
GO:0044237 cellular metabolic process
GO:0046483 heterocycle metabolic process
GO:0006725 cellular aromatic compound metabolic process
GO:0006519 cellular amino acid and derivative metabolic process
GO:0044249 cellular biosynthetic process
GO:0006575 cellular amino acid derivative metabolic process
GO:0019438 aromatic compound biosynthetic process
GO:0009404 toxin metabolic process
GO:0043385 mycotoxin metabolic process
GO:0009698 phenylpropanoid metabolic process
GO:0042398 cellular amino acid derivative biosynthetic process
GO:0009403 toxin biosynthetic process
GO:0009804 coumarin metabolic process
GO:0043386 mycotoxin biosynthetic process
GO:0009699 phenylpropanoid biosynthetic process
GO:0009805 coumarin biosynthetic process
GO:0046222 aflatoxin metabolic process
GO:0045122 aflatoxin biosynthetic process

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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17ms
Stand-alone
Hostnametomcat-8.ebi.ac.uk
Uptime17:46 13/10/2009
Data version2009-11-29-04-02-58
Terminal
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