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GO:0044212 transcription regulatory region DNA binding

Term Information

ID GO:0044212
Name transcription regulatory region DNA binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
Comment The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
GONUTS GO:0044212 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink
Considerations when annotating from ChiP assay resultsLink

Cross-references

Database ID
InterPro IPR011615
InterPro IPR028372

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0010843 promoter binding CONSIDER GO:0044212

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0044212:
Relationship To GO:0044212 Child Term Child Term Name
Regulates GO:2000677 regulation of transcription regulatory region DNA binding
Negatively regulates GO:2000678 negative regulation of transcription regulatory region DNA binding
Positively regulates GO:2000679 positive regulation of transcription regulatory region DNA binding
Is a GO:0001047 core promoter binding
Is a GO:0035326 enhancer binding
Is a GO:0032422 purine-rich negative regulatory element binding
Is a GO:0044213 intronic transcription regulatory region DNA binding
Is a GO:0032810 sterol response element binding
Is a GO:0010736 serum response element binding
Is a GO:0034056 estrogen response element binding
Is a GO:0035497 cAMP response element binding
Is a GO:0035538 carbohydrate response element binding
Is a GO:0044323 retinoic acid-responsive element binding
Is a GO:0070361 mitochondrial light strand promoter anti-sense binding
Is a GO:0070362 mitochondrial heavy strand promoter anti-sense binding
Is a GO:0070363 mitochondrial light strand promoter sense binding
Is a GO:0070364 mitochondrial heavy strand promoter sense binding
Is a GO:0070594 juvenile hormone response element binding
Is a GO:0070644 vitamin D response element binding
Is a GO:0070888 E-box binding
Is a GO:0071820 N-box binding
Is a GO:0000976 transcription regulatory region sequence-specific DNA binding
Is a GO:0001012 RNA polymerase II regulatory region DNA binding
Is a GO:0001013 RNA polymerase I regulatory region DNA binding
Is a GO:0001016 RNA polymerase III regulatory region DNA binding
Is a GO:0001017 bacterial-type RNA polymerase regulatory region DNA binding
Is a GO:0001018 mitochondrial RNA polymerase regulatory region DNA binding
Is a GO:0001019 plastid RNA polymerase regulatory region DNA binding
Is a GO:0001160 transcription termination site DNA binding
Is a GO:0001159 core promoter proximal region DNA binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0044212. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0044212 based on the entire annotation set Co-occurrence statistics for GO:0044212 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-09-03 Updated TERM transcription regulatory region DNA binding
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2010-09-03 Deleted DEFINITION Interacting selectively with a DNA sequence that controls the expression of a gene.
2010-09-03 Added RELATION is a GO:0000975 (regulatory region DNA binding)
2010-09-03 Deleted RELATION is a GO:0003677 (DNA binding)
2009-11-06 Added TERM DNA regulatory region binding
2009-11-06 Added DEFINITION Interacting selectively with a DNA sequence that controls the expression of a gene.
2009-11-06 Added RELATION is a GO:0003677 (DNA binding)

Term

Timestamp Action Category Detail
2010-09-03 Updated TERM transcription regulatory region DNA binding
2009-11-06 Added TERM DNA regulatory region binding

Definition/synonyms

Timestamp Action Category Detail
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2010-09-03 Deleted DEFINITION Interacting selectively with a DNA sequence that controls the expression of a gene.
2009-11-06 Added DEFINITION Interacting selectively with a DNA sequence that controls the expression of a gene.

Relationships

Timestamp Action Category Detail
2010-09-03 Added RELATION is a GO:0000975 (regulatory region DNA binding)
2010-09-03 Deleted RELATION is a GO:0003677 (DNA binding)
2009-11-06 Added RELATION is a GO:0003677 (DNA binding)
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