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GO:0043626 PCNA complexA protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
Term Information
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| Type | Synonym |
| broad | sliding clamp |
| exact | PCNA homotrimer |
| exact | proliferating cell nuclear antigen complex |
| Database | ID |
| INTERPRO | IPR000730 |
GO:0005660 delta-DNA polymerase cofactor complex |
(replaced_by GO:0043626) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0005575 cellular_component | |||||||
![]() | GO:0005623 cell | ||||||
![]() | ![]() | GO:0032991 macromolecular complex | |||||
![]() | ![]() | ![]() | GO:0043234 protein complex | ||||
![]() | ![]() | ![]() | ![]() | GO:0044464 cell part | |||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0005622 intracellular | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044424 intracellular part | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0043626 PCNA complex |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-24-04-03-40 |