spacer

GO:0043626 PCNA complex

Term Information

ID GO:0043626
Name PCNA complex
Ontology Cellular Component
Definition A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
PMID:12829735
GONUTS GO:0043626 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact proliferating cell nuclear antigen complex
broad sliding clamp
exact PCNA homotrimer

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct pcna_human PCNA homotrimer
IntAct pcna_yeast PCNA homotrimer

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005660 delta-DNA polymerase cofactor complex REPLACEDBY GO:0043626

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043626:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043626. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043626 based on the entire annotation set Co-occurrence statistics for GO:0043626 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-08-31 Deleted RELATION is a GO:0044424 (intracellular part)
2013-08-31 Deleted RELATION is a GO:0043234 (protein complex)
2013-08-31 Added RELATION is a GO:0044796 (DNA polymerase processivity factor complex)
2008-08-24 Added SYNONYM PCNA homotrimer
2008-05-13 Added DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2008-05-12 Deleted DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2008-04-01 Updated RELATION is a GO:0044424 (intracellular part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM proliferating cell nuclear antigen complex
2007-08-09 Added SYNONYM sliding clamp
2007-08-09 Deleted SYNONYM sliding clamp
2007-08-09 Deleted SYNONYM proliferating cell nuclear antigen complex
2007-07-12 Added SYNONYM sliding clamp
2006-03-11 Added TERM PCNA complex
2006-03-11 Added DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2006-03-11 Added SYNONYM proliferating cell nuclear antigen complex

Term

Timestamp Action Category Detail
2006-03-11 Added TERM PCNA complex

Definition/synonyms

Timestamp Action Category Detail
2008-08-24 Added SYNONYM PCNA homotrimer
2008-05-13 Added DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2008-05-12 Deleted DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2007-08-09 Added SYNONYM proliferating cell nuclear antigen complex
2007-08-09 Added SYNONYM sliding clamp
2007-08-09 Deleted SYNONYM sliding clamp
2007-08-09 Deleted SYNONYM proliferating cell nuclear antigen complex
2007-07-12 Added SYNONYM sliding clamp
2006-03-11 Added DEFINITION A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
2006-03-11 Added SYNONYM proliferating cell nuclear antigen complex

Relationships

Timestamp Action Category Detail
2013-08-31 Deleted RELATION is a GO:0044424 (intracellular part)
2013-08-31 Deleted RELATION is a GO:0043234 (protein complex)
2013-08-31 Added RELATION is a GO:0044796 (DNA polymerase processivity factor complex)
2008-04-01 Updated RELATION is a GO:0044424 (intracellular part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms