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GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

Term Information

ID GO:0043540
Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
Ontology Cellular Component
Definition A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
Comment Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
GONUTS GO:0043540 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
narrow 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex
narrow 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex
narrow 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct pfkfb1-pfkb1_human 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 1 homodimer
IntAct pfkfb3-pfkb3_human 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 3 homodimer
IntAct pfkfb4-pfkb4_human 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 4 homodimer
IntAct pfkfb4-pfkb4_rat 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 4 homodimer

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043540:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043540. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043540 based on the entire annotation set Co-occurrence statistics for GO:0043540 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-08-09 Updated TERM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-05-13 Added DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2008-05-12 Deleted DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2005-11-27 Added DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2005-11-27 Added TERM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex

Term

Timestamp Action Category Detail
2014-08-09 Updated TERM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
2005-11-27 Added TERM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex

Definition/synonyms

Timestamp Action Category Detail
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex
2014-08-09 Added SYNONYM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex
2008-05-13 Added DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2008-05-12 Deleted DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2005-11-27 Added DEFINITION A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.

Relationships

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
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