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GO:0043409 negative regulation of MAPK cascade

Term Information

ID GO:0043409
Name negative regulation of MAPK cascade
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
GONUTS GO:0043409 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact negative regulation of MAP kinase kinase kinase cascade
exact negative regulation of mitogen-activated protein kinase kinase kinase cascade
exact downregulation of MAPKKK cascade
exact down-regulation of MAPKKK cascade
exact down regulation of MAPKKK cascade
exact negative regulation of mitogen-activated protein kinase cascade
exact negative regulation of mitogen activated protein kinase cascade
exact negative regulation of MAPKKK cascade
exact negative regulation of MAP kinase cascade
exact downregulation of MAPK cascade
exact down regulation of MAPK cascade
narrow inhibition of MAPK cascade
exact down-regulation of MAPK cascade
exact negative regulation of mitogen activated protein kinase kinase kinase cascade
narrow inhibition of MAPKKK cascade

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043409:
Relationship To GO:0043409 Child Term Child Term Name
Is a GO:0032873 negative regulation of stress-activated MAPK cascade
Is a GO:0070373 negative regulation of ERK1 and ERK2 cascade
Is a GO:0070377 negative regulation of ERK5 cascade
Is a GO:1903138 negative regulation of MAPK cascade involved in cell wall organization or biogenesis
Is a GO:0043407 negative regulation of MAP kinase activity
Is a GO:0051389 inactivation of MAPKK activity
Is a GO:0051390 inactivation of MAPKKK activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043409. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043409 based on the entire annotation set Co-occurrence statistics for GO:0043409 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-04 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2013-11-28 Added RELATION is a GO:0042326 (negative regulation of phosphorylation)
2012-01-27 Added SYNONYM downregulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAP kinase cascade
2012-01-27 Added SYNONYM down-regulation of MAPK cascade
2012-01-27 Added SYNONYM inhibition of MAPK cascade
2012-01-27 Added SYNONYM down regulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAPKKK cascade
2012-01-27 Added SYNONYM negative regulation of mitogen activated protein kinase cascade
2012-01-27 Added SYNONYM negative regulation of mitogen-activated protein kinase cascade
2012-01-27 Updated TERM negative regulation of MAPK cascade
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-10-02 Added RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2008-10-02 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-04-01 Added RELATION negatively regulates GO:0000165 (MAPK cascade)
2008-04-01 Updated RELATION is a GO:0043408 (regulation of MAPK cascade)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
2007-08-09 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM down regulation of MAPKKK cascade
2007-08-09 Added SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Added SYNONYM downregulation of MAPKKK cascade
2007-08-09 Added SYNONYM inhibition of MAPKKK cascade
2007-08-09 Deleted SYNONYM down regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM downregulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM inhibition of MAPKKK cascade
2007-08-09 Deleted SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-02-23 Added SYNONYM down regulation of MAPKKK cascade
2007-02-23 Added SYNONYM down-regulation of MAPKKK cascade
2007-02-23 Added SYNONYM downregulation of MAPKKK cascade
2007-02-23 Added SYNONYM inhibition of MAPKKK cascade
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added TERM negative regulation of MAPKKK cascade
2005-07-04 Added DEFINITION Any process that stops, prevents or reduces the rate of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2005-07-04 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2005-07-04 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade

Term

Timestamp Action Category Detail
2012-01-27 Updated TERM negative regulation of MAPK cascade
2005-07-04 Added TERM negative regulation of MAPKKK cascade

Definition/synonyms

Timestamp Action Category Detail
2012-01-27 Added SYNONYM downregulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAP kinase cascade
2012-01-27 Added SYNONYM down-regulation of MAPK cascade
2012-01-27 Added SYNONYM inhibition of MAPK cascade
2012-01-27 Added SYNONYM down regulation of MAPK cascade
2012-01-27 Added SYNONYM negative regulation of MAPKKK cascade
2012-01-27 Added SYNONYM negative regulation of mitogen activated protein kinase cascade
2012-01-27 Added SYNONYM negative regulation of mitogen-activated protein kinase cascade
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2007-08-09 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-08-09 Added SYNONYM down regulation of MAPKKK cascade
2007-08-09 Added SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Added SYNONYM downregulation of MAPKKK cascade
2007-08-09 Added SYNONYM inhibition of MAPKKK cascade
2007-08-09 Deleted SYNONYM down regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM down-regulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM downregulation of MAPKKK cascade
2007-08-09 Deleted SYNONYM inhibition of MAPKKK cascade
2007-08-09 Deleted SYNONYM negative regulation of MAP kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade
2007-02-23 Added SYNONYM down regulation of MAPKKK cascade
2007-02-23 Added SYNONYM down-regulation of MAPKKK cascade
2007-02-23 Added SYNONYM downregulation of MAPKKK cascade
2007-02-23 Added SYNONYM inhibition of MAPKKK cascade
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added DEFINITION Any process that stops, prevents or reduces the rate of signal transduction mediated by the MAPKKK cascade.
2005-07-04 Added SYNONYM negative regulation of MAP kinase kinase kinase cascade
2005-07-04 Added SYNONYM negative regulation of mitogen activated protein kinase kinase kinase cascade
2005-07-04 Added SYNONYM negative regulation of mitogen-activated protein kinase kinase kinase cascade

Relationships

Timestamp Action Category Detail
2013-12-04 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2013-11-28 Added RELATION is a GO:0042326 (negative regulation of phosphorylation)
2008-10-02 Added RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2008-10-02 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-04-01 Added RELATION negatively regulates GO:0000165 (MAPK cascade)
2008-04-01 Updated RELATION is a GO:0043408 (regulation of MAPK cascade)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
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