spacer

GO:0043224 nuclear SCF ubiquitin ligase complex

Term Information

ID GO:0043224
Name nuclear SCF ubiquitin ligase complex
Ontology Cellular Component
Definition A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
PMID:15571813 PMID:15688063
GONUTS GO:0043224 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact nuclear SCF complex
exact nuclear Skp1/Cul1/F-box protein complex
exact nuclear cullin complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043224:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043224. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043224 based on the entire annotation set Co-occurrence statistics for GO:0043224 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-04-24 Added RELATION part of GO:0005634 (nucleus)
2013-02-02 Deleted RELATION part of GO:0005634 (nucleus)
2012-10-29 Added RELATION part of GO:0005634 (nucleus)
2008-05-13 Added DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-04-01 Updated RELATION is a GO:0019005 (SCF ubiquitin ligase complex)
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)
2007-08-09 Added SYNONYM nuclear SCF complex
2007-08-09 Added SYNONYM nuclear Skp1/Cul1/F-box protein complex
2007-08-09 Added SYNONYM nuclear cullin complex
2007-08-09 Deleted SYNONYM nuclear SCF complex
2007-08-09 Deleted SYNONYM nuclear Skp1/Cul1/F-box protein complex
2007-08-09 Deleted SYNONYM nuclear cullin complex
2006-09-22 Updated DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2005-06-11 Updated DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome.The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2004-10-08 Added SYNONYM nuclear SCF complex
2004-10-08 Added SYNONYM nuclear Skp1/Cul1/F-box protein complex
2004-10-08 Added SYNONYM nuclear cullin complex
2004-10-08 Added DEFINITION A protein complex, located in the nucleus, usually consisting of three conserved polypeptides (named Skp1, Cdc53/Cul1, Rbx1/Hrt1 in yeast and mammals) and one variable polypeptide (F-box protein), which is involved in the targeting of proteins for proteasome degradation.
2004-10-08 Added TERM nuclear SCF ubiquitin ligase complex

Term

Timestamp Action Category Detail
2004-10-08 Added TERM nuclear SCF ubiquitin ligase complex

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2007-08-09 Added SYNONYM nuclear SCF complex
2007-08-09 Added SYNONYM nuclear Skp1/Cul1/F-box protein complex
2007-08-09 Added SYNONYM nuclear cullin complex
2007-08-09 Deleted SYNONYM nuclear SCF complex
2007-08-09 Deleted SYNONYM nuclear Skp1/Cul1/F-box protein complex
2007-08-09 Deleted SYNONYM nuclear cullin complex
2006-09-22 Updated DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2005-06-11 Updated DEFINITION A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome.The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2004-10-08 Added SYNONYM nuclear SCF complex
2004-10-08 Added SYNONYM nuclear Skp1/Cul1/F-box protein complex
2004-10-08 Added SYNONYM nuclear cullin complex
2004-10-08 Added DEFINITION A protein complex, located in the nucleus, usually consisting of three conserved polypeptides (named Skp1, Cdc53/Cul1, Rbx1/Hrt1 in yeast and mammals) and one variable polypeptide (F-box protein), which is involved in the targeting of proteins for proteasome degradation.

Relationships

Timestamp Action Category Detail
2015-04-24 Added RELATION part of GO:0005634 (nucleus)
2013-02-02 Deleted RELATION part of GO:0005634 (nucleus)
2012-10-29 Added RELATION part of GO:0005634 (nucleus)
2008-04-01 Updated RELATION is a GO:0019005 (SCF ubiquitin ligase complex)
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
15ms