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GO:0043121 neurotrophin binding

Term Information

ID GO:0043121
Name neurotrophin binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Secondary IDs GO:0048404 GO:0048405
GONUTS GO:0043121 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow NT3 binding
related neurotrophin TRKA receptor activity
related neurotrophin TRKC receptor activity
narrow NT-4 binding
narrow NT-3 binding
related neurotrophin TRKB receptor activity
narrow neurotrophin 4/5 binding
narrow neurotrophin-3 binding
narrow neurotrophin 3 binding
related neurotrophin TRK receptor activity
narrow NT5 binding
narrow neurotrophin-4/5 binding
exact NT 4/5 binding
narrow NT-4/5 binding
narrow NT4 binding
narrow NT-5 binding

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0019838 growth factor binding never_in_taxon 2, 2157, 4751 Fungi or Bacteria or Archaea
More information on taxon constraints in GO is available here

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005013 obsolete neurotrophin TRK receptor activity CONSIDER GO:0043121
GO:0005014 obsolete neurotrophin TRKA receptor activity CONSIDER GO:0043121
GO:0005015 obsolete neurotrophin TRKB receptor activity CONSIDER GO:0043121
GO:0005016 obsolete neurotrophin TRKC receptor activity CONSIDER GO:0043121

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043121:
Relationship To GO:0043121 Child Term Child Term Name
Is a GO:0048403 brain-derived neurotrophic factor binding
Is a GO:0048406 nerve growth factor binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043121. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043121 based on the entire annotation set Co-occurrence statistics for GO:0043121 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-07-06 Deleted DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2013-07-06 Added DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
2013-03-29 Deleted DEFINITION Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2013-03-29 Added DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2012-03-24 Added SYNONYM NT 4/5 binding
2012-03-24 Added SYNONYM NT5 binding
2012-03-24 Added SYNONYM NT3 binding
2012-03-24 Added SYNONYM NT4 binding
2012-03-24 Added SYNONYM neurotrophin 3 binding
2012-03-24 Added SYNONYM neurotrophin-3 binding
2012-03-24 Added SYNONYM NT-4/5 binding
2012-03-24 Added SYNONYM NT-5 binding
2012-03-24 Added SYNONYM neurotrophin TRKA receptor activity
2012-03-24 Added SYNONYM neurotrophin TRKC receptor activity
2012-03-24 Added SYNONYM neurotrophin-4/5 binding
2012-03-24 Added SYNONYM NT-3 binding
2012-03-24 Added SYNONYM NT-4 binding
2012-03-24 Added SYNONYM neurotrophin 4/5 binding
2012-03-24 Added SYNONYM neurotrophin TRKB receptor activity
2012-03-24 Added SECONDARY GO:0048405 (neurotrophin-4/5 binding)
2012-03-24 Added SECONDARY GO:0048404 (neurotrophin-3 binding)
2011-10-28 Added RELATION has part GO:0005030 (neurotrophin receptor activity)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2009-07-03 Deleted DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2008-05-13 Added DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2008-05-12 Deleted DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2008-04-01 Updated RELATION is a GO:0019838 (growth factor binding)
2007-08-09 Added SYNONYM neurotrophin TRK receptor activity
2007-08-09 Deleted SYNONYM neurotrophin TRK receptor activity
2005-08-10 Added SYNONYM neurotrophin TRK receptor activity
2004-03-03 Added DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2004-03-03 Added TERM neurotrophin binding

Term

Timestamp Action Category Detail
2004-03-03 Added TERM neurotrophin binding

Definition/synonyms

Timestamp Action Category Detail
2013-07-06 Deleted DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2013-07-06 Added DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
2013-03-29 Deleted DEFINITION Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2013-03-29 Added DEFINITION Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2012-03-24 Added SYNONYM NT 4/5 binding
2012-03-24 Added SYNONYM NT5 binding
2012-03-24 Added SYNONYM NT3 binding
2012-03-24 Added SYNONYM NT4 binding
2012-03-24 Added SYNONYM neurotrophin 3 binding
2012-03-24 Added SYNONYM neurotrophin-3 binding
2012-03-24 Added SYNONYM NT-4/5 binding
2012-03-24 Added SYNONYM NT-5 binding
2012-03-24 Added SYNONYM neurotrophin TRKA receptor activity
2012-03-24 Added SYNONYM neurotrophin TRKC receptor activity
2012-03-24 Added SYNONYM neurotrophin-4/5 binding
2012-03-24 Added SYNONYM NT-3 binding
2012-03-24 Added SYNONYM NT-4 binding
2012-03-24 Added SYNONYM neurotrophin 4/5 binding
2012-03-24 Added SYNONYM neurotrophin TRKB receptor activity
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2009-07-03 Deleted DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2008-05-13 Added DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2008-05-12 Deleted DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.
2007-08-09 Added SYNONYM neurotrophin TRK receptor activity
2007-08-09 Deleted SYNONYM neurotrophin TRK receptor activity
2005-08-10 Added SYNONYM neurotrophin TRK receptor activity
2004-03-03 Added DEFINITION Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth.

Relationships

Timestamp Action Category Detail
2011-10-28 Added RELATION has part GO:0005030 (neurotrophin receptor activity)
2008-04-01 Updated RELATION is a GO:0019838 (growth factor binding)

Other

Timestamp Action Category Detail
2012-03-24 Added SECONDARY GO:0048405 (neurotrophin-4/5 binding)
2012-03-24 Added SECONDARY GO:0048404 (neurotrophin-3 binding)
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