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GO:0043086 negative regulation of catalytic activity

Term Information

ID GO:0043086
Name negative regulation of catalytic activity
Ontology Biological Process
Definition Any process that stops or reduces the activity of an enzyme.
GONUTS GO:0043086 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact down-regulation of enzyme activity
exact downregulation of enzyme activity
narrow inhibition of enzyme activity
exact down regulation of enzyme activity
exact negative regulation of enzyme activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR014453
InterPro IPR029785
InterPro IPR029913
InterPro IPR029914
InterPro IPR029916

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043086:
Relationship To GO:0043086 Child Term Child Term Name
Is a GO:0051346 negative regulation of hydrolase activity
Is a GO:0051348 negative regulation of transferase activity
Is a GO:0051350 negative regulation of lyase activity
Is a GO:0051352 negative regulation of ligase activity
Is a GO:0051354 negative regulation of oxidoreductase activity
Is a GO:0048553 negative regulation of metalloenzyme activity
Is a GO:0031280 negative regulation of cyclase activity
Is a GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction
Part of GO:0004857 enzyme inhibitor activity
Is a GO:2000362 negative regulation of prostaglandin-E synthase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0043086. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0043086 based on the entire annotation set Co-occurrence statistics for GO:0043086 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2010-06-14 Deleted RELATION negatively regulates GO:0003824 (catalytic activity)
2010-06-09 Updated TERM negative regulation of catalytic activity
2010-06-08 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2010-06-08 Updated TERM negative regulation of catalytic activity
2009-04-29 Added RELATION is a GO:0044092 (negative regulation of molecular function)
2009-02-25 Updated TERM negative regulation of catalytic activity
2009-02-25 Deleted RELATION negatively regulates GO:0003824 (catalytic activity)
2009-02-22 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2009-02-22 Updated TERM negative regulation of catalytic activity
2008-05-13 Added DEFINITION Any process that stops or reduces the activity of an enzyme.
2008-05-12 Deleted DEFINITION Any process that stops or reduces the activity of an enzyme.
2008-04-01 Updated RELATION is a GO:0050790 (regulation of catalytic activity)
2007-11-08 Updated TERM negative regulation of catalytic activity
2007-11-08 Added SYNONYM negative regulation of enzyme activity
2007-08-09 Added SYNONYM down regulation of enzyme activity
2007-08-09 Added SYNONYM down-regulation of enzyme activity
2007-08-09 Added SYNONYM downregulation of enzyme activity
2007-08-09 Added SYNONYM inhibition of enzyme activity
2007-08-09 Deleted SYNONYM down regulation of enzyme activity
2007-08-09 Deleted SYNONYM down-regulation of enzyme activity
2007-08-09 Deleted SYNONYM downregulation of enzyme activity
2007-08-09 Deleted SYNONYM inhibition of enzyme activity
2007-02-23 Added SYNONYM down regulation of enzyme activity
2007-02-23 Added SYNONYM down-regulation of enzyme activity
2007-02-23 Added SYNONYM downregulation of enzyme activity
2007-02-23 Added SYNONYM inhibition of enzyme activity
2004-01-28 Added DEFINITION Any process that stops or reduces the activity of an enzyme.
2004-01-28 Added TERM negative regulation of enzyme activity

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM negative regulation of catalytic activity
2010-06-08 Updated TERM negative regulation of catalytic activity
2009-02-25 Updated TERM negative regulation of catalytic activity
2009-02-22 Updated TERM negative regulation of catalytic activity
2007-11-08 Updated TERM negative regulation of catalytic activity
2004-01-28 Added TERM negative regulation of enzyme activity

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that stops or reduces the activity of an enzyme.
2008-05-12 Deleted DEFINITION Any process that stops or reduces the activity of an enzyme.
2007-11-08 Added SYNONYM negative regulation of enzyme activity
2007-08-09 Added SYNONYM down regulation of enzyme activity
2007-08-09 Added SYNONYM down-regulation of enzyme activity
2007-08-09 Added SYNONYM downregulation of enzyme activity
2007-08-09 Added SYNONYM inhibition of enzyme activity
2007-08-09 Deleted SYNONYM down regulation of enzyme activity
2007-08-09 Deleted SYNONYM down-regulation of enzyme activity
2007-08-09 Deleted SYNONYM downregulation of enzyme activity
2007-08-09 Deleted SYNONYM inhibition of enzyme activity
2007-02-23 Added SYNONYM down regulation of enzyme activity
2007-02-23 Added SYNONYM down-regulation of enzyme activity
2007-02-23 Added SYNONYM downregulation of enzyme activity
2007-02-23 Added SYNONYM inhibition of enzyme activity
2004-01-28 Added DEFINITION Any process that stops or reduces the activity of an enzyme.

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2010-06-14 Deleted RELATION negatively regulates GO:0003824 (catalytic activity)
2010-06-08 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2009-04-29 Added RELATION is a GO:0044092 (negative regulation of molecular function)
2009-02-25 Deleted RELATION negatively regulates GO:0003824 (catalytic activity)
2009-02-22 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2008-04-01 Updated RELATION is a GO:0050790 (regulation of catalytic activity)
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