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GO:0042824 MHC class I peptide loading complex

Term Information

ID GO:0042824
Name MHC class I peptide loading complex
Ontology Cellular Component
Definition A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
PMID:10631934
Comment Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
GONUTS GO:0042824 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related PLC
exact peptide-loading complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0005783 endoplasmic reticulum only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir456

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042824:
Relationship To GO:0042824 Child Term Child Term Name
Part of GO:0042825 TAP complex
Part of GO:0061779 Tapasin-ERp57 complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Name
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Type
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042824. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042824 based on the entire annotation set Co-occurrence statistics for GO:0042824 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-08-07 Added SYNONYM peptide-loading complex
2016-08-07 Added SYNONYM PLC
2016-08-07 Added RELATION capable of part of GO:0002502 (peptide antigen assembly with MHC class I protein complex)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-06-25 Deleted RELATION is a GO:0044425 (membrane part)
2015-05-11 Added RELATION is a GO:0098796 (membrane protein complex)
2013-04-18 Updated SLIM goslim_pir
2010-10-11 Added RELATION is a GO:0044425 (membrane part)
2010-08-04 Added RELATION part of GO:0030176 (integral component of endoplasmic reticulum membrane)
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2008-05-12 Deleted DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044432 (endoplasmic reticulum part)
2003-10-31 Updated DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2003-08-08 Added TERM MHC class I peptide loading complex
2003-08-08 Added DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthetised MHC class I molecules.

Term

Timestamp Action Category Detail
2003-08-08 Added TERM MHC class I peptide loading complex

Definition/synonyms

Timestamp Action Category Detail
2016-08-07 Added SYNONYM peptide-loading complex
2016-08-07 Added SYNONYM PLC
2008-05-13 Added DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2008-05-12 Deleted DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2003-10-31 Updated DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
2003-08-08 Added DEFINITION A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthetised MHC class I molecules.

Relationships

Timestamp Action Category Detail
2016-08-07 Added RELATION capable of part of GO:0002502 (peptide antigen assembly with MHC class I protein complex)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-06-25 Deleted RELATION is a GO:0044425 (membrane part)
2015-05-11 Added RELATION is a GO:0098796 (membrane protein complex)
2010-10-11 Added RELATION is a GO:0044425 (membrane part)
2010-08-04 Added RELATION part of GO:0030176 (integral component of endoplasmic reticulum membrane)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044432 (endoplasmic reticulum part)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2008-06-09 Added SLIM goslim_pir
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