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GO:0042535 positive regulation of tumor necrosis factor biosynthetic process

Term Information

ID GO:0042535
Name positive regulation of tumor necrosis factor biosynthetic process
Ontology Biological Process
Definition Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
PMID:10891884
Comment Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
GONUTS GO:0042535 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact positive regulation of TNF alpha biosynthesis
exact upregulation of tumor necrosis factor biosynthetic process
exact positive regulation of TNF alpha biosynthetic process
exact positive regulation of TNF biosynthesis
exact positive regulation of TNF biosynthetic process
exact positive regulation of TNF-alpha biosynthesis
exact positive regulation of TNF-alpha biosynthetic process
exact positive regulation of tumor necrosis factor anabolism
exact positive regulation of tumor necrosis factor biosynthesis
exact positive regulation of tumor necrosis factor formation
exact positive regulation of tumor necrosis factor synthesis
exact positive regulation of tumor necrosis factor-alpha biosynthesis
exact positive regulation of tumor necrosis factor-alpha biosynthetic process
narrow stimulation of tumor necrosis factor biosynthetic process
exact up regulation of tumor necrosis factor biosynthetic process
exact up-regulation of tumor necrosis factor biosynthetic process
narrow activation of tumor necrosis factor biosynthetic process

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042535:
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Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042535. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042535 based on the entire annotation set Co-occurrence statistics for GO:0042535 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-04-01 Added RELATION positively regulates GO:0042533 (tumor necrosis factor biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042534 (regulation of tumor necrosis factor biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042108 (positive regulation of cytokine biosynthetic process)
2007-08-09 Added SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM activation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF alpha biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF-alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor anabolism
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor formation
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor synthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-08-09 Added SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM activation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor anabolism
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor formation
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-08-09 Deleted SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF alpha biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF alpha biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF-alpha biosynthesis
2007-03-06 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-03-04 Deleted SYNONYM stimulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM up regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM up-regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM upregulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM activation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha anabolism
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha formation
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha synthesis
2007-03-04 Added SYNONYM positive regulation of TNF biosynthesis
2007-03-04 Added SYNONYM positive regulation of TNF biosynthetic process
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor anabolism
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor formation
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor synthesis
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Added SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM activation of tumor necrosis factor biosynthetic process
2007-03-04 Updated TERM positive regulation of tumor necrosis factor biosynthetic process
2007-02-23 Added SYNONYM activation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM stimulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM up regulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM up-regulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM upregulation of tumor necrosis factor-alpha biosynthetic process
2007-01-15 Updated TERM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of TNF alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2006-05-04 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-10-21 Updated DEFINITION Any process that activates or increases the rate, frequency or extent of biosynthesis of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha anabolism
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha formation
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha synthesis
2004-04-19 Added SYNONYM positive regulation of TNF alpha biosynthesis
2004-04-19 Added SYNONYM positive regulation of TNF-alpha biosynthesis
2004-04-16 Deleted SYNONYM positive regulation of TNF alpha biosynthesis
2004-04-16 Deleted SYNONYM positive regulation of TNF-alpha biosynthesis
2002-11-27 Added DEFINITION Any process that activates or increases the rate of biosynthesis of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2002-08-29 Added SYNONYM positive regulation of TNF alpha biosynthesis
2002-08-29 Added SYNONYM positive regulation of TNF-alpha biosynthesis
2002-08-29 Added TERM positive regulation of tumor necrosis factor-alpha biosynthesis

Term

Timestamp Action Category Detail
2007-03-04 Updated TERM positive regulation of tumor necrosis factor biosynthetic process
2007-01-15 Updated TERM positive regulation of tumor necrosis factor-alpha biosynthetic process
2002-08-29 Added TERM positive regulation of tumor necrosis factor-alpha biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-05-12 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-08-09 Added SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM activation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF alpha biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF biosynthetic process
2007-08-09 Added SYNONYM positive regulation of TNF-alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor anabolism
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor formation
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor synthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2007-08-09 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-08-09 Added SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-08-09 Added SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM activation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor anabolism
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor formation
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-08-09 Deleted SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF alpha biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-08-09 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF alpha biosynthesis
2007-08-09 Deleted SYNONYM positive regulation of TNF-alpha biosynthesis
2007-03-06 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-03-04 Deleted SYNONYM stimulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM up regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM up-regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM upregulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM activation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha anabolism
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha formation
2007-03-04 Deleted SYNONYM positive regulation of tumor necrosis factor-alpha synthesis
2007-03-04 Added SYNONYM positive regulation of TNF biosynthesis
2007-03-04 Added SYNONYM positive regulation of TNF biosynthetic process
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor anabolism
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor biosynthesis
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor formation
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor synthesis
2007-03-04 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthetic process
2007-03-04 Added SYNONYM stimulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM up regulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM up-regulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM upregulation of tumor necrosis factor biosynthetic process
2007-03-04 Added SYNONYM activation of tumor necrosis factor biosynthetic process
2007-02-23 Added SYNONYM activation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM stimulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM up regulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM up-regulation of tumor necrosis factor-alpha biosynthetic process
2007-02-23 Added SYNONYM upregulation of tumor necrosis factor-alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of TNF alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of TNF-alpha biosynthetic process
2007-01-15 Added SYNONYM positive regulation of tumor necrosis factor-alpha biosynthesis
2006-05-04 Updated DEFINITION Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-10-21 Updated DEFINITION Any process that activates or increases the rate, frequency or extent of biosynthesis of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha anabolism
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha formation
2005-08-10 Added SYNONYM positive regulation of tumor necrosis factor-alpha synthesis
2004-04-19 Added SYNONYM positive regulation of TNF alpha biosynthesis
2004-04-19 Added SYNONYM positive regulation of TNF-alpha biosynthesis
2004-04-16 Deleted SYNONYM positive regulation of TNF alpha biosynthesis
2004-04-16 Deleted SYNONYM positive regulation of TNF-alpha biosynthesis
2002-11-27 Added DEFINITION Any process that activates or increases the rate of biosynthesis of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2002-08-29 Added SYNONYM positive regulation of TNF alpha biosynthesis
2002-08-29 Added SYNONYM positive regulation of TNF-alpha biosynthesis

Relationships

Timestamp Action Category Detail
2008-04-01 Added RELATION positively regulates GO:0042533 (tumor necrosis factor biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042534 (regulation of tumor necrosis factor biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042108 (positive regulation of cytokine biosynthetic process)
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