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GO:0042533 tumor necrosis factor biosynthetic process

Term Information

ID GO:0042533
Name tumor necrosis factor biosynthetic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
PMID:10891884
Comment Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
GONUTS GO:0042533 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact TNF alpha biosynthesis
exact TNF alpha biosynthetic process
exact TNF biosynthesis
exact TNF biosynthetic process
exact TNF-alpha biosynthesis
exact tumor necrosis factor synthesis
exact Tumor Necrosis Factor alpha biosynthesis
exact Tumor Necrosis Factor alpha biosynthetic process
exact tumor necrosis factor anabolism
exact tumor necrosis factor biosynthesis
exact tumor necrosis factor formation
exact TNF-alpha biosynthetic process

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000299 GO:0032501 multicellular organismal process only_in_taxon 2759 Eukaryota
GOTAX:0000537 GO:0032501 multicellular organismal process never_in_taxon 4932 Saccharomyces cerevisiae
GOTAX:0000538 GO:0032501 multicellular organismal process never_in_taxon 4896 Schizosaccharomyces pombe
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042533:
Relationship To GO:0042533 Child Term Child Term Name
Regulates GO:0042534 regulation of tumor necrosis factor biosynthetic process
Positively regulates GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Negatively regulates GO:0042536 negative regulation of tumor necrosis factor biosynthetic process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042533. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042533 based on the entire annotation set Co-occurrence statistics for GO:0042533 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-04-01 Updated RELATION is a GO:0042089 (cytokine biosynthetic process)
2008-04-01 Updated RELATION part of GO:0032640 (tumor necrosis factor production)
2007-08-09 Added SYNONYM TNF alpha biosynthesis
2007-08-09 Added SYNONYM TNF alpha biosynthetic process
2007-08-09 Added SYNONYM TNF biosynthesis
2007-08-09 Added SYNONYM TNF biosynthetic process
2007-08-09 Added SYNONYM TNF-alpha biosynthesis
2007-08-09 Added SYNONYM TNF-alpha biosynthetic process
2007-08-09 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2007-08-09 Added SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-08-09 Added SYNONYM tumor necrosis factor anabolism
2007-08-09 Added SYNONYM tumor necrosis factor biosynthesis
2007-08-09 Added SYNONYM tumor necrosis factor formation
2007-08-09 Added SYNONYM tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM TNF biosynthesis
2007-08-09 Deleted SYNONYM TNF biosynthetic process
2007-08-09 Deleted SYNONYM tumor necrosis factor anabolism
2007-08-09 Deleted SYNONYM tumor necrosis factor biosynthesis
2007-08-09 Deleted SYNONYM tumor necrosis factor formation
2007-08-09 Deleted SYNONYM tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM TNF alpha biosynthetic process
2007-08-09 Deleted SYNONYM TNF-alpha biosynthetic process
2007-08-09 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-08-09 Deleted SYNONYM TNF alpha biosynthesis
2007-08-09 Deleted SYNONYM TNF-alpha biosynthesis
2007-08-09 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthesis
2007-03-06 Updated DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha anabolism
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha formation
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha synthesis
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha biosynthesis
2007-03-04 Added SYNONYM TNF biosynthesis
2007-03-04 Added SYNONYM TNF biosynthetic process
2007-03-04 Added SYNONYM tumor necrosis factor anabolism
2007-03-04 Added SYNONYM tumor necrosis factor biosynthesis
2007-03-04 Added SYNONYM tumor necrosis factor formation
2007-03-04 Added SYNONYM tumor necrosis factor synthesis
2007-03-04 Updated TERM tumor necrosis factor biosynthetic process
2007-01-15 Updated TERM tumor necrosis factor-alpha biosynthetic process
2007-01-15 Added SYNONYM TNF alpha biosynthetic process
2007-01-15 Added SYNONYM TNF-alpha biosynthetic process
2007-01-15 Added SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-01-15 Added SYNONYM tumor necrosis factor-alpha biosynthesis
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-08-10 Added SYNONYM tumor necrosis factor-alpha anabolism
2005-08-10 Added SYNONYM tumor necrosis factor-alpha formation
2005-08-10 Added SYNONYM tumor necrosis factor-alpha synthesis
2004-04-19 Added SYNONYM TNF alpha biosynthesis
2004-04-19 Added SYNONYM TNF-alpha biosynthesis
2004-04-19 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2004-04-16 Deleted SYNONYM TNF alpha biosynthesis
2004-04-16 Deleted SYNONYM TNF-alpha biosynthesis
2004-04-16 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthesis
2003-03-19 Deleted SYNONYM llymphotoxin biosynthesis
2002-11-27 Added DEFINITION The formation from simpler components of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2002-08-29 Added SYNONYM TNF alpha biosynthesis
2002-08-29 Added SYNONYM TNF-alpha biosynthesis
2002-08-29 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2002-08-29 Added SYNONYM llymphotoxin biosynthesis
2002-08-29 Added TERM tumor necrosis factor-alpha biosynthesis

Term

Timestamp Action Category Detail
2007-03-04 Updated TERM tumor necrosis factor biosynthetic process
2007-01-15 Updated TERM tumor necrosis factor-alpha biosynthetic process
2002-08-29 Added TERM tumor necrosis factor-alpha biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-08-09 Added SYNONYM TNF alpha biosynthesis
2007-08-09 Added SYNONYM TNF alpha biosynthetic process
2007-08-09 Added SYNONYM TNF biosynthesis
2007-08-09 Added SYNONYM TNF biosynthetic process
2007-08-09 Added SYNONYM TNF-alpha biosynthesis
2007-08-09 Added SYNONYM TNF-alpha biosynthetic process
2007-08-09 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2007-08-09 Added SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-08-09 Added SYNONYM tumor necrosis factor anabolism
2007-08-09 Added SYNONYM tumor necrosis factor biosynthesis
2007-08-09 Added SYNONYM tumor necrosis factor formation
2007-08-09 Added SYNONYM tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM TNF biosynthesis
2007-08-09 Deleted SYNONYM TNF biosynthetic process
2007-08-09 Deleted SYNONYM tumor necrosis factor anabolism
2007-08-09 Deleted SYNONYM tumor necrosis factor biosynthesis
2007-08-09 Deleted SYNONYM tumor necrosis factor formation
2007-08-09 Deleted SYNONYM tumor necrosis factor synthesis
2007-08-09 Deleted SYNONYM TNF alpha biosynthetic process
2007-08-09 Deleted SYNONYM TNF-alpha biosynthetic process
2007-08-09 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-08-09 Deleted SYNONYM TNF alpha biosynthesis
2007-08-09 Deleted SYNONYM TNF-alpha biosynthesis
2007-08-09 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthesis
2007-03-06 Updated DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha anabolism
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha formation
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha synthesis
2007-03-04 Deleted SYNONYM tumor necrosis factor-alpha biosynthesis
2007-03-04 Added SYNONYM TNF biosynthesis
2007-03-04 Added SYNONYM TNF biosynthetic process
2007-03-04 Added SYNONYM tumor necrosis factor anabolism
2007-03-04 Added SYNONYM tumor necrosis factor biosynthesis
2007-03-04 Added SYNONYM tumor necrosis factor formation
2007-03-04 Added SYNONYM tumor necrosis factor synthesis
2007-01-15 Added SYNONYM TNF alpha biosynthetic process
2007-01-15 Added SYNONYM TNF-alpha biosynthetic process
2007-01-15 Added SYNONYM Tumor Necrosis Factor alpha biosynthetic process
2007-01-15 Added SYNONYM tumor necrosis factor-alpha biosynthesis
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2005-08-10 Added SYNONYM tumor necrosis factor-alpha anabolism
2005-08-10 Added SYNONYM tumor necrosis factor-alpha formation
2005-08-10 Added SYNONYM tumor necrosis factor-alpha synthesis
2004-04-19 Added SYNONYM TNF alpha biosynthesis
2004-04-19 Added SYNONYM TNF-alpha biosynthesis
2004-04-19 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2004-04-16 Deleted SYNONYM TNF alpha biosynthesis
2004-04-16 Deleted SYNONYM TNF-alpha biosynthesis
2004-04-16 Deleted SYNONYM Tumor Necrosis Factor alpha biosynthesis
2003-03-19 Deleted SYNONYM llymphotoxin biosynthesis
2002-11-27 Added DEFINITION The formation from simpler components of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2002-08-29 Added SYNONYM TNF alpha biosynthesis
2002-08-29 Added SYNONYM TNF-alpha biosynthesis
2002-08-29 Added SYNONYM Tumor Necrosis Factor alpha biosynthesis
2002-08-29 Added SYNONYM llymphotoxin biosynthesis

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042089 (cytokine biosynthetic process)
2008-04-01 Updated RELATION part of GO:0032640 (tumor necrosis factor production)
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