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GO:0042500 aspartic endopeptidase activity, intramembrane cleaving

Term Information

ID GO:0042500
Name aspartic endopeptidase activity, intramembrane cleaving
Ontology Molecular Function
Definition Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.
Comment Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
GONUTS GO:0042500 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.23.-

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0042499 signal peptide peptidase activity REPLACEDBY GO:0042500

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042500:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042500. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042500 based on the entire annotation set Co-occurrence statistics for GO:0042500 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-04-01 Updated RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2003-04-24 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2003-03-25 Updated TERM aspartic endopeptidase activity, intramembrane cleaving
2003-03-19 Updated TERM aspartic endopeptidase, intramembrane cleaving activity
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of non-terminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2002-08-24 Added XREF EC:3.4.23.-
2002-08-24 Added TERM aspartic endopeptidase, intramembrane cleaving

Term

Timestamp Action Category Detail
2003-03-25 Updated TERM aspartic endopeptidase activity, intramembrane cleaving
2003-03-19 Updated TERM aspartic endopeptidase, intramembrane cleaving activity
2002-08-24 Added TERM aspartic endopeptidase, intramembrane cleaving

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2003-04-24 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of non-terminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004190 (aspartic-type endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2002-08-24 Added XREF EC:3.4.23.-
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