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GO:0042380 hydroxymethylbutenyl pyrophosphate reductase activity

Term Information

ID GO:0042380
Name hydroxymethylbutenyl pyrophosphate reductase activity
Ontology Molecular Function
Definition Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
Comment Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined.
GONUTS GO:0042380 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042380:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042380. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042380 based on the entire annotation set Co-occurrence statistics for GO:0042380 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2008-05-12 Deleted DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2008-04-01 Updated RELATION is a GO:0016491 (oxidoreductase activity)
2007-08-09 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2007-08-09 Deleted SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2004-04-19 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2004-04-16 Deleted SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2003-08-06 Updated DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2003-03-19 Updated TERM hydroxymethylbutenyl pyrophosphate reductase activity
2002-11-27 Added DEFINITION Catalyzes the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2002-07-16 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2002-07-16 Added TERM hydroxymethylbutenyl pyrophosphate reductase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM hydroxymethylbutenyl pyrophosphate reductase activity
2002-07-16 Added TERM hydroxymethylbutenyl pyrophosphate reductase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2008-05-12 Deleted DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2007-08-09 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2007-08-09 Deleted SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2004-04-19 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2004-04-16 Deleted SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
2003-08-06 Updated DEFINITION Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2002-11-27 Added DEFINITION Catalyzes the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
2002-07-16 Added SYNONYM (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016491 (oxidoreductase activity)
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