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GO:0042289 MHC class II protein binding

Term Information

ID GO:0042289
Name MHC class II protein binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
Comment Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
GONUTS GO:0042289 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact major histocompatibility complex class II binding
narrow major histocompatibility complex class II ligand

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

Cross-references

Database ID
InterPro IPR011988
InterPro IPR015386

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042289:
Relationship To GO:0042289 Child Term Child Term Name
Is a GO:0042657 MHC class II protein binding, via lateral surface
Is a GO:0042658 MHC class II protein binding, via antigen binding groove

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042289. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042289 based on the entire annotation set Co-occurrence statistics for GO:0042289 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-10-28 Added RELATION has part GO:0032395 (MHC class II receptor activity)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2009-07-03 Deleted DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2008-05-13 Added DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2008-05-12 Deleted DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2008-04-01 Updated RELATION is a GO:0042287 (MHC protein binding)
2007-08-09 Added SYNONYM major histocompatibility complex class II binding
2007-08-09 Added SYNONYM major histocompatibility complex class II ligand
2007-08-09 Deleted SYNONYM major histocompatibility complex class II binding
2007-08-09 Deleted SYNONYM major histocompatibility complex class II ligand
2006-11-03 Deleted SYNONYM gamma-delta T cell receptor activity
2006-11-03 Deleted SYNONYM alpha-beta T cell receptor activity
2006-11-03 Deleted SYNONYM T cell receptor activity
2006-09-29 Updated DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2005-08-10 Added SYNONYM T cell receptor activity
2005-08-10 Added SYNONYM alpha-beta T cell receptor activity
2005-08-10 Added SYNONYM gamma-delta T cell receptor activity
2004-04-19 Added SYNONYM major histocompatibility complex class II binding
2004-04-16 Deleted SYNONYM major histocompatibility complex class II binding
2003-06-10 Updated TERM MHC class II protein binding
2003-03-26 Updated DEFINITION Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2003-03-19 Updated TERM MHC class II protein binding activity
2003-03-19 Deleted SYNONYM MHC class II binding
2003-03-19 Deleted SYNONYM MHC class II ligand
2003-03-04 Updated TERM MHC class II molecule binding
2003-03-04 Added SYNONYM major histocompatibility complex class II binding
2003-03-04 Added SYNONYM major histocompatibility complex class II ligand
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2002-06-07 Added TERM major histocompatibility complex class II molecule binding
2002-06-07 Added SYNONYM MHC class II binding
2002-06-07 Added SYNONYM MHC class II ligand

Term

Timestamp Action Category Detail
2003-06-10 Updated TERM MHC class II protein binding
2003-03-19 Updated TERM MHC class II protein binding activity
2003-03-04 Updated TERM MHC class II molecule binding
2002-06-07 Added TERM major histocompatibility complex class II molecule binding

Definition/synonyms

Timestamp Action Category Detail
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2009-07-03 Deleted DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2008-05-13 Added DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2008-05-12 Deleted DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2007-08-09 Added SYNONYM major histocompatibility complex class II binding
2007-08-09 Added SYNONYM major histocompatibility complex class II ligand
2007-08-09 Deleted SYNONYM major histocompatibility complex class II binding
2007-08-09 Deleted SYNONYM major histocompatibility complex class II ligand
2006-11-03 Deleted SYNONYM gamma-delta T cell receptor activity
2006-11-03 Deleted SYNONYM alpha-beta T cell receptor activity
2006-11-03 Deleted SYNONYM T cell receptor activity
2006-09-29 Updated DEFINITION Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2005-08-10 Added SYNONYM T cell receptor activity
2005-08-10 Added SYNONYM alpha-beta T cell receptor activity
2005-08-10 Added SYNONYM gamma-delta T cell receptor activity
2004-04-19 Added SYNONYM major histocompatibility complex class II binding
2004-04-16 Deleted SYNONYM major histocompatibility complex class II binding
2003-03-26 Updated DEFINITION Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2003-03-19 Deleted SYNONYM MHC class II binding
2003-03-19 Deleted SYNONYM MHC class II ligand
2003-03-04 Added SYNONYM major histocompatibility complex class II binding
2003-03-04 Added SYNONYM major histocompatibility complex class II ligand
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
2002-06-07 Added SYNONYM MHC class II binding
2002-06-07 Added SYNONYM MHC class II ligand

Relationships

Timestamp Action Category Detail
2011-10-28 Added RELATION has part GO:0032395 (MHC class II receptor activity)
2008-04-01 Updated RELATION is a GO:0042287 (MHC protein binding)
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