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GO:0042282 hydroxymethylglutaryl-CoA reductase activityCatalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+.
Term Information
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| Type | Synonym |
| exact | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| exact | 3-hydroxy-3-methylglutaryl coenzyme A reductase activity |
| exact | (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating) |
| broad | hydroxymethylglutaryl coenzyme A reductase activity |
| broad | beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity |
| broad | beta-hydroxy-beta-methylglutaryl CoA-reductase activity |
| broad | 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity |
| broad | HMG-CoA reductase activity |
| Database | ID |
| MetaCyc | HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN |
| EC | 1.1.1.88 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||
![]() | GO:0003824 catalytic activity | ||||
![]() | ![]() | GO:0016491 oxidoreductase activity | |||
![]() | ![]() | ![]() | GO:0016614 oxidoreductase activity, acting on CH-OH group of donors | ||
![]() | ![]() | ![]() | ![]() | GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
![]() | ![]() | ![]() | ![]() | ![]() | GO:0042282 hydroxymethylglutaryl-CoA reductase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-23-04-03-36 |