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GO:0042267 natural killer cell mediated cytotoxicity

The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

Term Information

ID GO:0042267
Name natural killer cell mediated cytotoxicity
Ontology Biological Process
Definition The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.

Synonyms

Type Synonym
related natural killer-cell mediated cytolysis
exact natural killer cell mediated cell death
exact natural killer cell mediated cell killing
related natural killer cell mediated cytolysis
related killer activity
exact NK cell mediated cytotoxicity
related NK cell mediated cytolysis
exact NK cell mediated cell killing
exact NK cell mediated cell death

This term can be used instead of these obsolete terms:

GO:0007583 killer activity (consider GO:0042267)

Web service: term information

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.

GO:0008150 biological_process
GO:0009987 cellular process
GO:0050896 response to stimulus
GO:0065007 biological regulation
GO:0016265 death
GO:0002376 immune system process
GO:0001906 cell killing
GO:0006950 response to stress
GO:0050789 regulation of biological process
GO:0048518 positive regulation of biological process
GO:0006952 defense response
GO:0006955 immune response
GO:0008219 cell death
GO:0050794 regulation of cellular process
GO:0012501 programmed cell death
GO:0002252 immune effector process
GO:0002443 leukocyte mediated immunity
GO:0006915 apoptosis
GO:0048522 positive regulation of cellular process
GO:0001909 leukocyte mediated cytotoxicity
GO:0045087 innate immune response
GO:0002449 lymphocyte mediated immunity
GO:0010941 regulation of cell death
GO:0043067 regulation of programmed cell death
GO:0010942 positive regulation of cell death
GO:0002228 natural killer cell mediated immunity
GO:0042981 regulation of apoptosis
GO:0043068 positive regulation of programmed cell death
GO:0012502 induction of programmed cell death
GO:0043065 positive regulation of apoptosis
GO:0006917 induction of apoptosis
GO:0042267 natural killer cell mediated cytotoxicity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0043320 natural killer cell degranulation
I GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target
NR GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
PR GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
R GO:0042269 regulation of natural killer cell mediated cytotoxicity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
Click on the 'Update' button to run the co-occurence calculation
IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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