spacer

GO:0042101 T cell receptor complex

Term Information

ID GO:0042101
Name T cell receptor complex
Ontology Cellular Component
Definition A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
GONUTS GO:0042101 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact TCR complex
related TCR
exact T-cell receptor complex
exact T-lymphocyte receptor complex
exact T lymphocyte receptor complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Cross-references

Database ID
Wikipedia T_cell_receptor

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0023007 ligand binding to T cell receptor CONSIDER GO:0042101
GO:0023009 initiation of T cell receptor signaling CONSIDER GO:0042101
GO:0023012 initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor CONSIDER GO:0042101

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0042101:
Relationship To GO:0042101 Child Term Child Term Name
Is a GO:0042105 alpha-beta T cell receptor complex
Is a GO:0042106 gamma-delta T cell receptor complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0042101. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0042101 based on the entire annotation set Co-occurrence statistics for GO:0042101 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-07-22 Added SYNONYM TCR complex
2013-07-22 Added RELATION has part GO:0036398 (TCR signalosome)
2009-09-11 Added SYNONYM TCR
2009-09-11 Deleted SYNONYM TCR
2009-03-06 Added XREF Wikipedia:T_cell_receptor
2009-01-12 Deleted RELATION part of GO:0001772 (immunological synapse)
2008-05-13 Added DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2008-05-12 Deleted DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2008-04-01 Updated RELATION is a GO:0044459 (plasma membrane part)
2008-04-01 Updated RELATION is a GO:0043235 (receptor complex)
2008-04-01 Updated RELATION part of GO:0001772 (immunological synapse)
2007-10-18 Added SYNONYM T-cell receptor complex
2007-10-18 Deleted SYNONYM T cell receptor complex
2007-08-09 Added SYNONYM T cell receptor complex
2007-08-09 Added SYNONYM T lymphocyte receptor complex
2007-08-09 Added SYNONYM T-lymphocyte receptor complex
2007-08-09 Added SYNONYM TCR
2007-08-09 Deleted SYNONYM T cell receptor complex
2007-08-09 Deleted SYNONYM T lymphocyte receptor complex
2007-08-09 Deleted SYNONYM T-lymphocyte receptor complex
2007-08-09 Deleted SYNONYM TCR
2007-05-27 Updated DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2005-06-02 Added SYNONYM T cell receptor complex
2005-06-02 Added SYNONYM T lymphocyte receptor complex
2005-06-02 Added SYNONYM T-lymphocyte receptor complex
2005-06-02 Updated TERM T cell receptor complex
2005-05-26 Updated DEFINITION A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation.
2004-04-19 Added SYNONYM TCR
2004-04-16 Deleted SYNONYM TCR
2003-03-26 Added DEFINITION A receptor complex usually consisting of a TCR- (T-cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T-cell activation.
2003-01-09 Added SYNONYM TCR
2002-02-19 Added TERM T-cell receptor complex

Term

Timestamp Action Category Detail
2005-06-02 Updated TERM T cell receptor complex
2002-02-19 Added TERM T-cell receptor complex

Definition/synonyms

Timestamp Action Category Detail
2013-07-22 Added SYNONYM TCR complex
2009-09-11 Added SYNONYM TCR
2009-09-11 Deleted SYNONYM TCR
2008-05-13 Added DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2008-05-12 Deleted DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2007-10-18 Added SYNONYM T-cell receptor complex
2007-10-18 Deleted SYNONYM T cell receptor complex
2007-08-09 Added SYNONYM T cell receptor complex
2007-08-09 Added SYNONYM T lymphocyte receptor complex
2007-08-09 Added SYNONYM T-lymphocyte receptor complex
2007-08-09 Added SYNONYM TCR
2007-08-09 Deleted SYNONYM T cell receptor complex
2007-08-09 Deleted SYNONYM T lymphocyte receptor complex
2007-08-09 Deleted SYNONYM T-lymphocyte receptor complex
2007-08-09 Deleted SYNONYM TCR
2007-05-27 Updated DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2005-06-02 Added SYNONYM T cell receptor complex
2005-06-02 Added SYNONYM T lymphocyte receptor complex
2005-06-02 Added SYNONYM T-lymphocyte receptor complex
2005-05-26 Updated DEFINITION A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation.
2004-04-19 Added SYNONYM TCR
2004-04-16 Deleted SYNONYM TCR
2003-03-26 Added DEFINITION A receptor complex usually consisting of a TCR- (T-cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T-cell activation.
2003-01-09 Added SYNONYM TCR

Relationships

Timestamp Action Category Detail
2013-07-22 Added RELATION has part GO:0036398 (TCR signalosome)
2009-01-12 Deleted RELATION part of GO:0001772 (immunological synapse)
2008-04-01 Updated RELATION is a GO:0044459 (plasma membrane part)
2008-04-01 Updated RELATION is a GO:0043235 (receptor complex)
2008-04-01 Updated RELATION part of GO:0001772 (immunological synapse)

Cross-references

Timestamp Action Category Detail
2009-03-06 Added XREF Wikipedia:T_cell_receptor
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
24ms