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GO:0039579 suppression by virus of host ISG15 activity

Term Information

ID GO:0039579
Name suppression by virus of host ISG15 activity
Ontology Biological Process
Definition Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
PMID:11157743 PMID:18604270
GONUTS GO:0039579 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating gene products that interact with other organisms Link

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
Viral ProcessesLink

Cross-references

Database ID
UniProtKB-KW Inhibition of host ISG15 by virus
VZ 723

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0039579:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0039579. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0039579 based on the entire annotation set Co-occurrence statistics for GO:0039579 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-06-24 Added RELATION is a GO:0039507 (suppression by virus of host molecular function)
2012-06-24 Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 Added XREF VZ:723
2012-06-24 Added TERM suppression by virus of host ISG15 activity
2012-06-24 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.

Term

Timestamp Action Category Detail
2012-06-24 Added TERM suppression by virus of host ISG15 activity

Definition/synonyms

Timestamp Action Category Detail
2012-06-24 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.

Relationships

Timestamp Action Category Detail
2012-06-24 Added RELATION is a GO:0039507 (suppression by virus of host molecular function)
2012-06-24 Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)

Cross-references

Timestamp Action Category Detail
2012-06-24 Added XREF VZ:723
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