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GO:0039576 suppression by virus of host JAK1 activity

Term Information

ID GO:0039576
Name suppression by virus of host JAK1 activity
Ontology Biological Process
Definition Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.
Secondary IDs GO:0039515
GONUTS GO:0039576 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact suppression by virus of host janus kinase 1 activity
narrow viral inhibition of tyrosine phosphorylation of host STAT protein
narrow inhibition of host JAK activity by virus
narrow suppression by virus of tyrosine phosphorylation of host STAT protein
narrow negative regulation by virus of tyrosine phosphorylation of host STAT protein
exact negative regulation by virus of host JAK

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating gene products that interact with other organisms Link
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
Viral ProcessesLink
signallingLink

Cross-references

Database ID
UniProtKB-KW Inhibition of host JAK1 by virus
VZ 784

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0039576:
Relationship To GO:0039576 Child Term Child Term Name
Is a GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
Is a GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding

Protein Annotation

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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0039576. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0039576 based on the entire annotation set Co-occurrence statistics for GO:0039576 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-21 Added SYNONYM suppression by virus of host janus kinase 1 activity
2013-05-09 Added SECONDARY GO:0039515 (suppression by virus of tyrosine phosphorylation of host STAT protein)
2013-05-09 Added SYNONYM negative regulation by virus of tyrosine phosphorylation of host STAT protein
2013-05-09 Added SYNONYM negative regulation by virus of host JAK
2013-05-09 Added SYNONYM inhibition of host JAK activity by virus
2013-05-09 Added SYNONYM suppression by virus of tyrosine phosphorylation of host STAT protein
2013-05-09 Added SYNONYM viral inhibition of tyrosine phosphorylation of host STAT protein
2012-06-24 Added RELATION is a GO:0039514 (suppression by virus of host JAK-STAT cascade)
2012-06-24 Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)
2012-06-24 Added XREF VZ:784
2012-06-24 Added TERM suppression by virus of host JAK1 activity
2012-06-24 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.

Term

Timestamp Action Category Detail
2012-06-24 Added TERM suppression by virus of host JAK1 activity

Definition/synonyms

Timestamp Action Category Detail
2013-12-21 Added SYNONYM suppression by virus of host janus kinase 1 activity
2013-05-09 Added SYNONYM negative regulation by virus of tyrosine phosphorylation of host STAT protein
2013-05-09 Added SYNONYM negative regulation by virus of host JAK
2013-05-09 Added SYNONYM inhibition of host JAK activity by virus
2013-05-09 Added SYNONYM suppression by virus of tyrosine phosphorylation of host STAT protein
2013-05-09 Added SYNONYM viral inhibition of tyrosine phosphorylation of host STAT protein
2012-06-24 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.

Relationships

Timestamp Action Category Detail
2012-06-24 Added RELATION is a GO:0039514 (suppression by virus of host JAK-STAT cascade)
2012-06-24 Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)

Cross-references

Timestamp Action Category Detail
2012-06-24 Added XREF VZ:784

Other

Timestamp Action Category Detail
2013-05-09 Added SECONDARY GO:0039515 (suppression by virus of tyrosine phosphorylation of host STAT protein)
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