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GO:0039563 suppression by virus of host STAT1 activity

Term Information

ID GO:0039563
Name suppression by virus of host STAT1 activity
Ontology Biological Process
Definition Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
Comment This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
GONUTS GO:0039563 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow Inhibition of host STAT1 by virus
narrow inhibition by virus of host STAT1 activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating gene products that interact with other organisms Link

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
Viral ProcessesLink
signallingLink

Cross-references

Database ID
UniProtKB-KW Inhibition of host STAT1 by virus
VZ 282

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0039563:
Relationship To GO:0039563 Child Term Child Term Name
Is a GO:0039565 suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process
Is a GO:0039566 suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1
Is a GO:0039567 suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus
Is a GO:0039568 suppression by virus of host STAT1 activity by inhibition of DNA binding
Is a GO:0039571 suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0039563. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0039563 based on the entire annotation set Co-occurrence statistics for GO:0039563 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-04-10 Added SYNONYM Inhibition of host STAT1 by virus
2015-04-10 Deleted SYNONYM Inhibition of host STAT1 by virus
2012-04-28 Added TERM suppression by virus of host STAT1 activity
2012-04-28 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
2012-04-28 Added SYNONYM inhibition by virus of host STAT1 activity
2012-04-28 Added SYNONYM Inhibition of host STAT1 by virus
2012-04-28 Added XREF VZ:282
2012-04-28 Added RELATION is a GO:0039562 (suppression by virus of host STAT activity)

Term

Timestamp Action Category Detail
2012-04-28 Added TERM suppression by virus of host STAT1 activity

Definition/synonyms

Timestamp Action Category Detail
2015-04-10 Added SYNONYM Inhibition of host STAT1 by virus
2015-04-10 Deleted SYNONYM Inhibition of host STAT1 by virus
2012-04-28 Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
2012-04-28 Added SYNONYM inhibition by virus of host STAT1 activity
2012-04-28 Added SYNONYM Inhibition of host STAT1 by virus

Relationships

Timestamp Action Category Detail
2012-04-28 Added RELATION is a GO:0039562 (suppression by virus of host STAT activity)

Cross-references

Timestamp Action Category Detail
2012-04-28 Added XREF VZ:282
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