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GO:0039529 RIG-I signaling pathway

Term Information

ID GO:0039529
Name RIG-I signaling pathway
Ontology Biological Process
Definition Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
PMID:17328678 PMID:19620789 PMID:21435580
Comment The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect.
GONUTS GO:0039529 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DDX58 signaling pathway
exact retinoic acid inducible gene I signaling pathway
exact RIG-I signalling pathway

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating gene products that interact with other organisms Link

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
Viral ProcessesLink
signallingLink

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0039529:
Relationship To GO:0039529 Child Term Child Term Name
Positively regulates GO:1900246 positive regulation of RIG-I signaling pathway
Negatively regulates GO:0039538 suppression by virus of host RIG-I signaling pathway
Regulates GO:0039535 regulation of RIG-I signaling pathway
Negatively regulates GO:0039536 negative regulation of RIG-I signaling pathway

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0039529. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0039529 based on the entire annotation set Co-occurrence statistics for GO:0039529 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-04-14 Added SYNONYM RIG-I signalling pathway
2011-12-22 Added RELATION is a GO:0039528 (cytoplasmic pattern recognition receptor signaling pathway in response to virus)
2011-12-22 Added SYNONYM retinoic acid inducible gene I signaling pathway
2011-12-22 Added SYNONYM DDX58 signaling pathway
2011-12-22 Added TERM RIG-I signaling pathway
2011-12-22 Added DEFINITION Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

Term

Timestamp Action Category Detail
2011-12-22 Added TERM RIG-I signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-04-14 Added SYNONYM RIG-I signalling pathway
2011-12-22 Added SYNONYM retinoic acid inducible gene I signaling pathway
2011-12-22 Added SYNONYM DDX58 signaling pathway
2011-12-22 Added DEFINITION Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

Relationships

Timestamp Action Category Detail
2011-12-22 Added RELATION is a GO:0039528 (cytoplasmic pattern recognition receptor signaling pathway in response to virus)
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