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GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus

Term Information

ID GO:0039528
Name cytoplasmic pattern recognition receptor signaling pathway in response to virus
Ontology Biological Process
Definition Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
PMID:17328678 PMID:18272355 PMID:19531363
Comment This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
GONUTS GO:0039528 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact cytoplasmic pattern recognition receptor signalling pathway in response to virus
exact virus-induced cytoplasmic pattern recognition receptor signaling pathway
narrow cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway
narrow RIG-like receptor signaling pathway
narrow RLH signaling pathway
narrow RIG-I/MDA5 signaling pathway
narrow RLR signaling pathway
narrow RIG-I-like receptor (RLR) signaling pathway
narrow RIG-like helicase signaling pathway

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating gene products that interact with other organisms Link

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
Viral ProcessesLink
signallingLink

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0039528:
Relationship To GO:0039528 Child Term Child Term Name
Is a GO:0039529 RIG-I signaling pathway
Is a GO:0039530 MDA-5 signaling pathway
Regulates GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
Negatively regulates GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
Negatively regulates GO:0039537 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0039528. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0039528 based on the entire annotation set Co-occurrence statistics for GO:0039528 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-02-17 Added RELATION is a GO:0044764 (multi-organism cellular process)
2014-01-29 Added RELATION is a GO:0098586 (cellular response to virus)
2012-04-29 Added RELATION is a GO:0001819 (positive regulation of cytokine production)
2012-04-14 Added SYNONYM cytoplasmic pattern recognition receptor signalling pathway in response to virus
2012-01-05 Added SYNONYM virus-induced cytoplasmic pattern recognition receptor signaling pathway
2011-12-22 Added RELATION part of GO:0051607 (defense response to virus)
2011-12-22 Added RELATION is a GO:0002753 (cytoplasmic pattern recognition receptor signaling pathway)
2011-12-22 Added SYNONYM RIG-like helicase signaling pathway
2011-12-22 Added SYNONYM RLH signaling pathway
2011-12-22 Added SYNONYM RIG-like receptor signaling pathway
2011-12-22 Added SYNONYM cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway
2011-12-22 Added SYNONYM RLR signaling pathway
2011-12-22 Added SYNONYM RIG-I/MDA5 signaling pathway
2011-12-22 Added SYNONYM RIG-I-like receptor (RLR) signaling pathway
2011-12-22 Added TERM cytoplasmic pattern recognition receptor signaling pathway in response to virus
2011-12-22 Added DEFINITION Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

Term

Timestamp Action Category Detail
2011-12-22 Added TERM cytoplasmic pattern recognition receptor signaling pathway in response to virus

Definition/synonyms

Timestamp Action Category Detail
2012-04-14 Added SYNONYM cytoplasmic pattern recognition receptor signalling pathway in response to virus
2012-01-05 Added SYNONYM virus-induced cytoplasmic pattern recognition receptor signaling pathway
2011-12-22 Added SYNONYM RIG-like helicase signaling pathway
2011-12-22 Added SYNONYM RLH signaling pathway
2011-12-22 Added SYNONYM RIG-like receptor signaling pathway
2011-12-22 Added SYNONYM cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway
2011-12-22 Added SYNONYM RLR signaling pathway
2011-12-22 Added SYNONYM RIG-I/MDA5 signaling pathway
2011-12-22 Added SYNONYM RIG-I-like receptor (RLR) signaling pathway
2011-12-22 Added DEFINITION Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

Relationships

Timestamp Action Category Detail
2014-02-17 Added RELATION is a GO:0044764 (multi-organism cellular process)
2014-01-29 Added RELATION is a GO:0098586 (cellular response to virus)
2012-04-29 Added RELATION is a GO:0001819 (positive regulation of cytokine production)
2011-12-22 Added RELATION part of GO:0051607 (defense response to virus)
2011-12-22 Added RELATION is a GO:0002753 (cytoplasmic pattern recognition receptor signaling pathway)
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