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GO:0038109 Kit signaling pathway

Term Information

ID GO:0038109
Name Kit signaling pathway
Ontology Biological Process
Definition A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
PMID:16129412
GONUTS GO:0038109 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact stem cell factor receptor signaling pathway
exact stem cell factor signaling pathway
exact SCF signaling pathway
exact Kit signalling pathway

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR027263

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0038109:
Relationship To GO:0038109 Child Term Child Term Name
Part of GO:0005020 stem cell factor receptor activity
Regulates GO:1900234 regulation of Kit signaling pathway
Negatively regulates GO:1900235 negative regulation of Kit signaling pathway
Positively regulates GO:1900236 positive regulation of Kit signaling pathway

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0038109. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0038109 based on the entire annotation set Co-occurrence statistics for GO:0038109 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-04-29 Added SYNONYM SCF signaling pathway
2012-04-29 Added RELATION is a GO:0036216 (cellular response to stem cell factor stimulus)
2012-04-14 Added SYNONYM Kit signalling pathway
2012-03-24 Added TERM Kit signaling pathway
2012-03-24 Added DEFINITION A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
2012-03-24 Added SYNONYM stem cell factor receptor signaling pathway
2012-03-24 Added SYNONYM stem cell factor signaling pathway
2012-03-24 Added RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
2012-03-24 Added RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)

Term

Timestamp Action Category Detail
2012-03-24 Added TERM Kit signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-04-29 Added SYNONYM SCF signaling pathway
2012-04-14 Added SYNONYM Kit signalling pathway
2012-03-24 Added DEFINITION A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
2012-03-24 Added SYNONYM stem cell factor receptor signaling pathway
2012-03-24 Added SYNONYM stem cell factor signaling pathway

Relationships

Timestamp Action Category Detail
2012-04-29 Added RELATION is a GO:0036216 (cellular response to stem cell factor stimulus)
2012-03-24 Added RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
2012-03-24 Added RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
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