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GO:0038049 ligand-activated RNA polymerase II transcription factor binding transcription factor activity

Term Information

ID GO:0038049
Name ligand-activated RNA polymerase II transcription factor binding transcription factor activity
Ontology Molecular Function
Definition Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.
Comment GO:0038049 is intended for annotation of nuclear receptors that regulate transcription by binding to transcription factors or transcription factor complexes. When the nuclear receptor functions by binding directly to DNA response elements, consider instead annotating to 'ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0004879'.
GONUTS GO:0038049 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related ligand-activated nuclear receptor activity
related ligand-dependent transcription factor activity

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0003706 ligand-regulated transcription factor activity CONSIDER GO:0038049
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0038049
GO:0072500 negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0038049
GO:2000190 negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0038049

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0038049:
Relationship To GO:0038049 Child Term Child Term Name
Is a GO:0038051 glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
Is a GO:0038053 estrogen-activated RNA polymerase II transcription factor binding transcription factor activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0038049. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0038049 based on the entire annotation set Co-occurrence statistics for GO:0038049 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-11-30 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-11-30 Added RELATION part of GO:0030522 (intracellular receptor signaling pathway)
2011-11-30 Added RELATION is a GO:0001076 (RNA polymerase II transcription factor binding transcription factor activity)
2011-11-30 Added SYNONYM ligand-dependent transcription factor activity
2011-11-30 Added SYNONYM ligand-activated nuclear receptor activity
2011-11-30 Added DEFINITION Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.
2011-11-30 Added TERM ligand-activated RNA polymerase II transcription factor binding transcription factor activity

Term

Timestamp Action Category Detail
2011-11-30 Added TERM ligand-activated RNA polymerase II transcription factor binding transcription factor activity

Definition/synonyms

Timestamp Action Category Detail
2011-11-30 Added SYNONYM ligand-dependent transcription factor activity
2011-11-30 Added SYNONYM ligand-activated nuclear receptor activity
2011-11-30 Added DEFINITION Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.

Relationships

Timestamp Action Category Detail
2011-11-30 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-11-30 Added RELATION part of GO:0030522 (intracellular receptor signaling pathway)
2011-11-30 Added RELATION is a GO:0001076 (RNA polymerase II transcription factor binding transcription factor activity)
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