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GO:0036378 calcitriol biosynthetic process from calciol

Term Information

ID GO:0036378
Name calcitriol biosynthetic process from calciol
Ontology Biological Process
Definition Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
PMID:17426122 PMID:20511049
GONUTS GO:0036378 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact vitamin D3 activation
exact calcitriol biosynthesis from calciol
broad 1alpha,25-dihydroxyvitamin D3 biosynthesis
broad 1alpha,25(OH)2D3 biosynthesis
broad 1alpha,25-dihydroxycholecalciferol biosynthesis

Cross-Ontology Relations

Relation Other Ontology ID Term
has_input CHEBI CHEBI:28940 calciol
has_output CHEBI CHEBI:17823 calcitriol

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0036378:
Relationship To GO:0036378 Child Term Child Term Name
Part of GO:0004498 calcidiol 1-monooxygenase activity
Part of GO:0030343 vitamin D3 25-hydroxylase activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0036378. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0036378 based on the entire annotation set Co-occurrence statistics for GO:0036378 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-06-20 Added RELATION is a GO:0042368 (vitamin D biosynthetic process)
2013-06-20 Deleted RELATION is a GO:0006694 (steroid biosynthetic process)
2013-06-20 Added RELATION is a GO:0046173 (polyol biosynthetic process)
2013-05-30 Updated TERM calcitriol biosynthetic process from calciol
2013-05-30 Deleted DEFINITION Conversion of vitamin D3 from its inactive form (calciol, also called cholecalciferol) into a biologically active form (calcitriol). Activation requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-30 Added DEFINITION Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-30 Added SYNONYM vitamin D3 activation
2013-05-30 Added RELATION is a GO:0044108 (cellular alcohol biosynthetic process)
2013-05-30 Added RELATION is a GO:0006694 (steroid biosynthetic process)
2013-05-30 Deleted RELATION is a GO:0070564 (positive regulation of vitamin D receptor signaling pathway)
2013-05-17 Added DEFINITION Conversion of vitamin D3 from its inactive form (calciol, also called cholecalciferol) into a biologically active form (calcitriol). Activation requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-17 Added TERM vitamin D3 activation
2013-05-17 Added RELATION is a GO:0070640 (vitamin D3 metabolic process)
2013-05-17 Added RELATION is a GO:0070564 (positive regulation of vitamin D receptor signaling pathway)
2013-05-17 Added SYNONYM 1alpha,25-dihydroxyvitamin D3 biosynthesis
2013-05-17 Added SYNONYM calcitriol biosynthesis from calciol
2013-05-17 Added SYNONYM 1alpha,25(OH)2D3 biosynthesis
2013-05-17 Added SYNONYM 1alpha,25-dihydroxycholecalciferol biosynthesis

Term

Timestamp Action Category Detail
2013-05-30 Updated TERM calcitriol biosynthetic process from calciol
2013-05-17 Added TERM vitamin D3 activation

Definition/synonyms

Timestamp Action Category Detail
2013-05-30 Deleted DEFINITION Conversion of vitamin D3 from its inactive form (calciol, also called cholecalciferol) into a biologically active form (calcitriol). Activation requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-30 Added DEFINITION Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-30 Added SYNONYM vitamin D3 activation
2013-05-17 Added DEFINITION Conversion of vitamin D3 from its inactive form (calciol, also called cholecalciferol) into a biologically active form (calcitriol). Activation requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
2013-05-17 Added SYNONYM 1alpha,25-dihydroxyvitamin D3 biosynthesis
2013-05-17 Added SYNONYM calcitriol biosynthesis from calciol
2013-05-17 Added SYNONYM 1alpha,25(OH)2D3 biosynthesis
2013-05-17 Added SYNONYM 1alpha,25-dihydroxycholecalciferol biosynthesis

Relationships

Timestamp Action Category Detail
2013-06-20 Added RELATION is a GO:0042368 (vitamin D biosynthetic process)
2013-06-20 Deleted RELATION is a GO:0006694 (steroid biosynthetic process)
2013-06-20 Added RELATION is a GO:0046173 (polyol biosynthetic process)
2013-05-30 Added RELATION is a GO:0044108 (cellular alcohol biosynthetic process)
2013-05-30 Added RELATION is a GO:0006694 (steroid biosynthetic process)
2013-05-30 Deleted RELATION is a GO:0070564 (positive regulation of vitamin D receptor signaling pathway)
2013-05-17 Added RELATION is a GO:0070640 (vitamin D3 metabolic process)
2013-05-17 Added RELATION is a GO:0070564 (positive regulation of vitamin D receptor signaling pathway)
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