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GO:0036166 phenotypic switching

Term Information

ID GO:0036166
Name phenotypic switching
Ontology Biological Process
Definition A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
PMID:12443899 PMID:22406749 PMID:8456504
Comment Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
GONUTS GO:0036166 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related phenotypic dimorphism

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0036166:
Relationship To GO:0036166 Child Term Child Term Name
Part of GO:0044663 establishment or maintenance of cell type involved in phenotypic switching
Regulates GO:0100057 regulation of phenotypic switching by transcription from RNA polymerase II promoter
Positively regulates GO:0100058 positive regulation of phenotypic switching by transcription from RNA polymerase II promoter
Negatively regulates GO:0100059 negative regulation of phenotypic switching by transcription from RNA polymerase II promoter
Is a GO:0036167 phenotypic switching in response to host
Regulates GO:1900239 regulation of phenotypic switching
Negatively regulates GO:1900240 negative regulation of phenotypic switching
Positively regulates GO:1900241 positive regulation of phenotypic switching
Part of GO:1900447 regulation of cell morphogenesis involved in phenotypic switching
Positively regulates GO:1900546 positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
Is a GO:0090677 reversible differentiation

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0036166. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0036166 based on the entire annotation set Co-occurrence statistics for GO:0036166 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-05-06 Deleted DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2016-05-06 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-12-23 Added RELATION is a GO:0009987 (cellular process)
2012-12-23 Deleted RELATION is a GO:0044699 (single-organism process)
2012-10-19 Added RELATION is a GO:0044699 (single-organism process)
2012-10-19 Deleted RELATION is a GO:0008150 (biological_process)
2012-08-10 Deleted DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-08-10 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-05-20 Deleted DEFINITION A reversible switch of a cell from one phenotype to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-05-20 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-03-29 Added RELATION is a GO:0008150 (biological_process)
2012-03-29 Added DEFINITION A reversible switch of a cell from one phenotype to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-03-29 Added SYNONYM phenotypic dimorphism
2012-03-29 Added TERM phenotypic switching

Term

Timestamp Action Category Detail
2012-03-29 Added TERM phenotypic switching

Definition/synonyms

Timestamp Action Category Detail
2016-05-06 Deleted DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2016-05-06 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-08-10 Deleted DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-08-10 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-05-20 Deleted DEFINITION A reversible switch of a cell from one phenotype to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-05-20 Added DEFINITION A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-03-29 Added DEFINITION A reversible switch of a cell from one phenotype to another, at a frequency above the expected frequency for somatic mutations. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2012-03-29 Added SYNONYM phenotypic dimorphism

Relationships

Timestamp Action Category Detail
2012-12-23 Added RELATION is a GO:0009987 (cellular process)
2012-12-23 Deleted RELATION is a GO:0044699 (single-organism process)
2012-10-19 Added RELATION is a GO:0044699 (single-organism process)
2012-10-19 Deleted RELATION is a GO:0008150 (biological_process)
2012-03-29 Added RELATION is a GO:0008150 (biological_process)
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