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GO:0036038 MKS complex

Term Information

ID GO:0036038
Name MKS complex
Ontology Cellular Component
Definition A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
PMID:21422230 PMID:21565611 PMID:21725307 PMID:22179047 PMID:25869670 PMID:26595381 PMID:26982032
Comment Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
GONUTS GO:0036038 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow B9 complex
narrow tectonic complex
narrow tectonic-like complex
exact MKS module
broad TCTN-B9D complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0005929 cilium never_in_taxon 3176 Zygnematales
GO:0005929 cilium never_in_taxon 3312 Coniferophyta
GO:0005929 cilium never_in_taxon 3378 Gnetales
GO:0005929 cilium never_in_taxon 3398 Magnoliophyta
GO:0005929 cilium never_in_taxon 4890 Ascomycota
GO:0005929 cilium never_in_taxon 5782 Dictyostelium
GO:0005929 cilium only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR019170

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0036038:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0036038. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0036038 based on the entire annotation set Co-occurrence statistics for GO:0036038 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-08-06 Added RELATION capable of part of GO:1905350 (Y-shaped link assembly)
2016-05-25 Updated TERM MKS complex
2016-05-25 Added SYNONYM TCTN-B9D complex
2016-05-25 Deleted DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
2016-05-25 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
2016-05-25 Added SYNONYM MKS module
2012-10-29 Added RELATION is a GO:0044441 (ciliary part)
2012-01-20 Updated TERM TCTN-B9D complex
2012-01-20 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
2012-01-20 Deleted DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a.
2012-01-20 Added SYNONYM tectonic-like complex
2012-01-20 Added SYNONYM tectonic complex
2012-01-20 Added SYNONYM B9 complex
2011-11-24 Added RELATION part of GO:0035869 (ciliary transition zone)
2011-11-24 Added RELATION is a GO:0043234 (protein complex)
2011-11-24 Added TERM tectonic complex
2011-11-24 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a.

Term

Timestamp Action Category Detail
2016-05-25 Updated TERM MKS complex
2012-01-20 Updated TERM TCTN-B9D complex
2011-11-24 Added TERM tectonic complex

Definition/synonyms

Timestamp Action Category Detail
2016-05-25 Added SYNONYM TCTN-B9D complex
2016-05-25 Deleted DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
2016-05-25 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
2016-05-25 Added SYNONYM MKS module
2012-01-20 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
2012-01-20 Deleted DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a.
2012-01-20 Added SYNONYM tectonic-like complex
2012-01-20 Added SYNONYM tectonic complex
2012-01-20 Added SYNONYM B9 complex
2011-11-24 Added DEFINITION A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a.

Relationships

Timestamp Action Category Detail
2016-08-06 Added RELATION capable of part of GO:1905350 (Y-shaped link assembly)
2012-10-29 Added RELATION is a GO:0044441 (ciliary part)
2011-11-24 Added RELATION part of GO:0035869 (ciliary transition zone)
2011-11-24 Added RELATION is a GO:0043234 (protein complex)
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