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GO:0035582 sequestering of BMP in extracellular matrix

Term Information

ID GO:0035582
Name sequestering of BMP in extracellular matrix
Ontology Biological Process
Definition Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
PMID:20855508
Comment Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
GONUTS GO:0035582 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact negative regulation of BMP signaling pathway by extracellular sequestering of BMP
exact negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP
exact negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
exact BMP sequestration in the ECM

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription processesLink

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035582:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0035582. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0035582 based on the entire annotation set Co-occurrence statistics for GO:0035582 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-03-01 Updated TERM sequestering of BMP in extracellular matrix
2012-03-01 Added DEFINITION Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
2012-03-01 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by binding or confining BMP within the extracellular region, such that it is separated from other components of the signaling pathway.
2012-03-01 Added SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
2012-03-01 Added SYNONYM BMP sequestration in the ECM
2012-03-01 Added SYNONYM negative regulation of BMP signaling pathway by extracellular sequestering of BMP
2012-03-01 Added SYNONYM negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP
2012-03-01 Deleted SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular sequestering of bone morphogenetic protein
2012-03-01 Deleted SYNONYM negative regulation of BMP signalling pathway by extracellular sequestering of BMP
2012-03-01 Added RELATION is a GO:0071694 (maintenance of protein location in extracellular region)
2010-11-17 Added SYNONYM negative regulation of BMP signalling pathway by extracellular sequestering of BMP
2010-10-14 Added RELATION is a GO:0030514 (negative regulation of BMP signaling pathway)
2010-10-14 Added RELATION is a GO:0035581 (sequestering of extracellular ligand from receptor)
2010-10-14 Added SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular sequestering of bone morphogenetic protein
2010-10-14 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by binding or confining BMP within the extracellular region, such that it is separated from other components of the signaling pathway.
2010-10-14 Added TERM negative regulation of BMP signaling pathway by extracellular sequestering of BMP

Term

Timestamp Action Category Detail
2012-03-01 Updated TERM sequestering of BMP in extracellular matrix
2010-10-14 Added TERM negative regulation of BMP signaling pathway by extracellular sequestering of BMP

Definition/synonyms

Timestamp Action Category Detail
2012-03-01 Added DEFINITION Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
2012-03-01 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by binding or confining BMP within the extracellular region, such that it is separated from other components of the signaling pathway.
2012-03-01 Added SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
2012-03-01 Added SYNONYM BMP sequestration in the ECM
2012-03-01 Added SYNONYM negative regulation of BMP signaling pathway by extracellular sequestering of BMP
2012-03-01 Added SYNONYM negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP
2012-03-01 Deleted SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular sequestering of bone morphogenetic protein
2012-03-01 Deleted SYNONYM negative regulation of BMP signalling pathway by extracellular sequestering of BMP
2010-11-17 Added SYNONYM negative regulation of BMP signalling pathway by extracellular sequestering of BMP
2010-10-14 Added SYNONYM negative regulation of bone morphogenetic protein signaling pathway by extracellular sequestering of bone morphogenetic protein
2010-10-14 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by binding or confining BMP within the extracellular region, such that it is separated from other components of the signaling pathway.

Relationships

Timestamp Action Category Detail
2012-03-01 Added RELATION is a GO:0071694 (maintenance of protein location in extracellular region)
2010-10-14 Added RELATION is a GO:0030514 (negative regulation of BMP signaling pathway)
2010-10-14 Added RELATION is a GO:0035581 (sequestering of extracellular ligand from receptor)
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