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GO:0009968 negative regulation of signal transduction

Term Information

ID GO:0009968
Name negative regulation of signal transduction
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
Secondary IDs GO:0035467
GONUTS GO:0009968 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related negative regulation of signalling pathway
exact down regulation of signal transduction
exact down-regulation of signal transduction
exact downregulation of signal transduction
related negative regulation of signaling pathway
narrow inhibition of signal transduction

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR012918
UniProtKB-KW Signal transduction inhibitor

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0009968:
Relationship To GO:0009968 Child Term Child Term Name
Is a GO:0070298 negative regulation of phosphorelay signal transduction system
Is a GO:2000734 negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
Is a GO:0060240 negative regulation of signal transduction involved in conjugation with cellular fusion
Is a GO:0075149 negative regulation of signal transduction in response to host
Is a GO:0075210 negative regulation by symbiont of host cAMP-mediated signal transduction
Is a GO:1900170 negative regulation of glucocorticoid mediated signaling pathway
Is a GO:0052004 negative regulation by symbiont of host salicylic acid-mediated defense response
Is a GO:1901099 negative regulation of signal transduction in absence of ligand
Is a GO:1901185 negative regulation of ERBB signaling pathway
Is a GO:1901188 negative regulation of ephrin receptor signaling pathway
Is a GO:1902045 negative regulation of Fas signaling pathway
Is a GO:1902203 negative regulation of hepatocyte growth factor receptor signaling pathway
Is a GO:1902842 negative regulation of netrin-activated signaling pathway
Is a GO:1902848 negative regulation of neuronal signal transduction
Is a GO:1900450 negative regulation of glutamate receptor signaling pathway
Is a GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
Is a GO:0001960 negative regulation of cytokine-mediated signaling pathway
Is a GO:0002156 negative regulation of thyroid hormone mediated signaling pathway
Is a GO:0009788 negative regulation of abscisic acid-activated signaling pathway
Is a GO:0009938 negative regulation of gibberellic acid mediated signaling pathway
Is a GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
Is a GO:0010930 negative regulation of auxin mediated signaling pathway
Is a GO:0016060 metarhodopsin inactivation
Is a GO:0022401 negative adaptation of signaling pathway
Is a GO:0023021 termination of signal transduction
Is a GO:0030178 negative regulation of Wnt signaling pathway
Is a GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
Is a GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway
Is a GO:0031586 negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Is a GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
Is a GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
Is a GO:0034122 negative regulation of toll-like receptor signaling pathway
Is a GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway
Is a GO:0035387 negative regulation of Roundabout signaling pathway
Is a GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
Is a GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
Is a GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Is a GO:0045746 negative regulation of Notch signaling pathway
Is a GO:0045751 negative regulation of Toll signaling pathway
Is a GO:0045873 negative regulation of sevenless signaling pathway
Is a GO:0045879 negative regulation of smoothened signaling pathway
Is a GO:0046627 negative regulation of insulin receptor signaling pathway
Is a GO:0048387 negative regulation of retinoic acid receptor signaling pathway
Is a GO:0050858 negative regulation of antigen receptor-mediated signaling pathway
Is a GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
Is a GO:0051395 negative regulation of nerve growth factor receptor activity
Is a GO:0060400 negative regulation of growth hormone receptor signaling pathway
Is a GO:0061060 negative regulation of peptidoglycan recognition protein signaling pathway
Is a GO:0070563 negative regulation of vitamin D receptor signaling pathway
Is a GO:0080037 negative regulation of cytokinin-activated signaling pathway
Is a GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Is a GO:0090229 negative regulation of red or far-red light signaling pathway
Is a GO:1900458 negative regulation of brassinosteroid mediated signaling pathway
Is a GO:1902069 negative regulation of sphingolipid mediated signaling pathway
Is a GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway
Is a GO:0038011 negative regulation of signal transduction by receptor internalization
Is a GO:2001045 negative regulation of integrin-mediated signaling pathway
Is a GO:2000639 negative regulation of SREBP signaling pathway
Is a GO:1902613 negative regulation of anti-Mullerian hormone signaling pathway
Is a GO:2000349 negative regulation of CD40 signaling pathway
Is a GO:2001234 negative regulation of apoptotic signaling pathway
Is a GO:2001261 negative regulation of semaphorin-plexin signaling pathway
Is a GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
Is a GO:1900116 extracellular negative regulation of signal transduction
Is a GO:1902532 negative regulation of intracellular signal transduction
Is a GO:1902660 negative regulation of glucose mediated signaling pathway

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0009968. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0009968 based on the entire annotation set Co-occurrence statistics for GO:0009968 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-01-30 Added RELATION is a GO:0048585 (negative regulation of response to stimulus)
2011-01-16 Added SYNONYM negative regulation of signaling pathway
2011-01-16 Added SYNONYM negative regulation of signalling pathway
2011-01-16 Added SECONDARY GO:0035467 (negative regulation of signaling pathway)
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
2010-02-20 Added RELATION is a GO:0023057 (negative regulation of signaling)
2008-10-21 Added RELATION is a GO:0010648 (negative regulation of cell communication)
2008-10-21 Deleted RELATION is a GO:0048523 (negative regulation of cellular process)
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2008-04-01 Updated RELATION is a GO:0048523 (negative regulation of cellular process)
2008-04-01 Added RELATION negatively regulates GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0009966 (regulation of signal transduction)
2007-08-09 Added SYNONYM inhibition of signal transduction
2007-08-09 Added SYNONYM down regulation of signal transduction
2007-08-09 Added SYNONYM down-regulation of signal transduction
2007-08-09 Added SYNONYM downregulation of signal transduction
2007-08-09 Deleted SYNONYM down regulation of signal transduction
2007-08-09 Deleted SYNONYM down-regulation of signal transduction
2007-08-09 Deleted SYNONYM downregulation of signal transduction
2007-08-09 Deleted SYNONYM inhibition of signal transduction
2007-02-23 Added SYNONYM down regulation of signal transduction
2007-02-23 Added SYNONYM down-regulation of signal transduction
2007-02-23 Added SYNONYM downregulation of signal transduction
2007-02-23 Added SYNONYM inhibition of signal transduction
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction.
2004-02-12 Updated DEFINITION Any process that stops, prevents or reduces the rate of signal transduction.
2003-03-26 Added DEFINITION Any process that reduces or prevents the rate of signal transduction.
2002-12-18 Added TERM negative regulation of signal transduction

Term

Timestamp Action Category Detail
2002-12-18 Added TERM negative regulation of signal transduction

Definition/synonyms

Timestamp Action Category Detail
2011-01-16 Added SYNONYM negative regulation of signaling pathway
2011-01-16 Added SYNONYM negative regulation of signalling pathway
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2007-08-09 Added SYNONYM inhibition of signal transduction
2007-08-09 Added SYNONYM down regulation of signal transduction
2007-08-09 Added SYNONYM down-regulation of signal transduction
2007-08-09 Added SYNONYM downregulation of signal transduction
2007-08-09 Deleted SYNONYM down regulation of signal transduction
2007-08-09 Deleted SYNONYM down-regulation of signal transduction
2007-08-09 Deleted SYNONYM downregulation of signal transduction
2007-08-09 Deleted SYNONYM inhibition of signal transduction
2007-02-23 Added SYNONYM down regulation of signal transduction
2007-02-23 Added SYNONYM down-regulation of signal transduction
2007-02-23 Added SYNONYM downregulation of signal transduction
2007-02-23 Added SYNONYM inhibition of signal transduction
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signal transduction.
2004-02-12 Updated DEFINITION Any process that stops, prevents or reduces the rate of signal transduction.
2003-03-26 Added DEFINITION Any process that reduces or prevents the rate of signal transduction.

Relationships

Timestamp Action Category Detail
2011-01-30 Added RELATION is a GO:0048585 (negative regulation of response to stimulus)
2010-02-20 Added RELATION is a GO:0023057 (negative regulation of signaling)
2008-10-21 Added RELATION is a GO:0010648 (negative regulation of cell communication)
2008-10-21 Deleted RELATION is a GO:0048523 (negative regulation of cellular process)
2008-04-01 Updated RELATION is a GO:0048523 (negative regulation of cellular process)
2008-04-01 Added RELATION negatively regulates GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0009966 (regulation of signal transduction)

Other

Timestamp Action Category Detail
2011-01-16 Added SECONDARY GO:0035467 (negative regulation of signaling pathway)
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