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GO:0035369 pre-B cell receptor complex

Term Information

ID GO:0035369
Name pre-B cell receptor complex
Ontology Cellular Component
Definition An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
PMID:16464608 PMID:17306522
Comment Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
GONUTS GO:0035369 Wiki Page

Synonyms

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Type Synonym
exact pre-BCR

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035369:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0035369. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0035369 based on the entire annotation set Co-occurrence statistics for GO:0035369 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-03-13 Added RELATION is a GO:0044425 (membrane part)
2010-03-13 Added RELATION is a GO:0043234 (protein complex)
2010-03-13 Added SYNONYM pre-BCR
2010-03-13 Added DEFINITION An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
2010-03-13 Added TERM pre-B cell receptor complex

Term

Timestamp Action Category Detail
2010-03-13 Added TERM pre-B cell receptor complex

Definition/synonyms

Timestamp Action Category Detail
2010-03-13 Added SYNONYM pre-BCR
2010-03-13 Added DEFINITION An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.

Relationships

Timestamp Action Category Detail
2010-03-13 Added RELATION is a GO:0044425 (membrane part)
2010-03-13 Added RELATION is a GO:0043234 (protein complex)
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