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GO:0035004 phosphatidylinositol 3-kinase activity

Term Information

ID GO:0035004
Name phosphatidylinositol 3-kinase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
PMID:10209156 PMID:9255069
GONUTS GO:0035004 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact phosphoinositide 3-kinase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.7.1.-
Wikipedia Phosphoinositide_3-kinase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035004:
Relationship To GO:0035004 Child Term Child Term Name
Regulates GO:0035014 phosphatidylinositol 3-kinase regulator activity
Regulates GO:0043551 regulation of phosphatidylinositol 3-kinase activity
Positively regulates GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
Negatively regulates GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity
Is a GO:0016303 1-phosphatidylinositol-3-kinase activity
Is a GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
Is a GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0035004. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0035004 based on the entire annotation set Co-occurrence statistics for GO:0035004 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-15 Deleted DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2012-01-15 Added DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
2012-01-08 Added RELATION is a GO:0016301 (kinase activity)
2012-01-08 Deleted RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2012-01-08 Deleted RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2012-01-08 Deleted RELATION is a GO:0001727 (lipid kinase activity)
2011-09-16 Added RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2011-09-16 Deleted RELATION is a GO:0004428 (inositol or phosphatidylinositol kinase activity)
2011-01-30 Updated TERM phosphatidylinositol 3-kinase activity
2011-01-30 Deleted DEFINITION Catalysis of the reaction: ATP + phosphoinositide = ADP + phosphoinositide 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2011-01-30 Added DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2011-01-30 Added SYNONYM phosphoinositide 3-kinase activity
2010-10-08 Added DEFINITION Catalysis of the reaction: ATP + phosphoinositide = ADP + phosphoinositide 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2010-10-08 Deleted DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2010-10-08 Deleted XREF MetaCyc:2.7.1.154-RXN
2010-06-15 Added RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2010-06-14 Deleted RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2010-06-08 Added RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2009-05-21 Added XREF MetaCyc:2.7.1.154-RXN
2009-02-25 Added XREF Wikipedia:Phosphoinositide_3-kinase
2008-05-13 Added DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2008-05-12 Deleted DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2008-04-01 Updated RELATION is a GO:0004428 (inositol or phosphatidylinositol kinase activity)
2008-04-01 Updated RELATION is a GO:0001727 (lipid kinase activity)
2003-08-28 Added XREF EC:2.7.1.-
2003-08-28 Added DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2003-08-28 Added TERM phosphoinositide 3-kinase activity

Term

Timestamp Action Category Detail
2011-01-30 Updated TERM phosphatidylinositol 3-kinase activity
2003-08-28 Added TERM phosphoinositide 3-kinase activity

Definition/synonyms

Timestamp Action Category Detail
2012-01-15 Deleted DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2012-01-15 Added DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
2011-01-30 Deleted DEFINITION Catalysis of the reaction: ATP + phosphoinositide = ADP + phosphoinositide 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2011-01-30 Added DEFINITION Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2011-01-30 Added SYNONYM phosphoinositide 3-kinase activity
2010-10-08 Added DEFINITION Catalysis of the reaction: ATP + phosphoinositide = ADP + phosphoinositide 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2010-10-08 Deleted DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2008-05-13 Added DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2008-05-12 Deleted DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
2003-08-28 Added DEFINITION Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].

Relationships

Timestamp Action Category Detail
2012-01-08 Added RELATION is a GO:0016301 (kinase activity)
2012-01-08 Deleted RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2012-01-08 Deleted RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2012-01-08 Deleted RELATION is a GO:0001727 (lipid kinase activity)
2011-09-16 Added RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2011-09-16 Deleted RELATION is a GO:0004428 (inositol or phosphatidylinositol kinase activity)
2010-06-15 Added RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2010-06-14 Deleted RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2010-06-08 Added RELATION part of GO:0046854 (phosphatidylinositol phosphorylation)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2008-04-01 Updated RELATION is a GO:0004428 (inositol or phosphatidylinositol kinase activity)
2008-04-01 Updated RELATION is a GO:0001727 (lipid kinase activity)

Cross-references

Timestamp Action Category Detail
2010-10-08 Deleted XREF MetaCyc:2.7.1.154-RXN
2009-05-21 Added XREF MetaCyc:2.7.1.154-RXN
2009-02-25 Added XREF Wikipedia:Phosphoinositide_3-kinase
2003-08-28 Added XREF EC:2.7.1.-
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