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GO:0033754 indoleamine 2,3-dioxygenase activity

Term Information

ID GO:0033754
Name indoleamine 2,3-dioxygenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
GONUTS GO:0033754 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad tryptophan pyrrolase activity
narrow D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
related IDO

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.13.11.52
MetaCyc RXN-8664
MetaCyc RXN-8665

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033754:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0033754. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0033754 based on the entire annotation set Co-occurrence statistics for GO:0033754 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate as the reaction catalyzed may be D-tryptophan + O2 = N-formyl-D-kynurenine, or L-tryptophan + O2 = N-formyl-L-kynurenine.
2011-09-16 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
2011-09-04 Deleted DEFINITION Catalysis of the reactions: tryptophan + O2 = N-formylkynurenine; D-tryptophan + O2 = N-formyl-D-kynurenine; and L-tryptophan + O2 = N-formyl-L-kynurenine.
2011-09-04 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate as the reaction catalyzed may be D-tryptophan + O2 = N-formyl-D-kynurenine, or L-tryptophan + O2 = N-formyl-L-kynurenine.
2010-09-15 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2010-09-15 Added DEFINITION Catalysis of the reactions: tryptophan + O2 = N-formylkynurenine; D-tryptophan + O2 = N-formyl-D-kynurenine; and L-tryptophan + O2 = N-formyl-L-kynurenine.
2009-05-21 Added XREF MetaCyc:RXN-8665
2009-05-21 Added XREF MetaCyc:RXN-8664
2008-05-13 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2008-04-01 Updated RELATION is a GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
2007-11-27 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2007-11-08 Added TERM indoleamine 2,3-dioxygenase activity
2007-11-08 Added SYNONYM D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
2007-11-08 Added SYNONYM IDO
2007-11-08 Added SYNONYM tryptophan pyrrolase activity
2007-11-08 Added XREF EC:1.13.11.52

Term

Timestamp Action Category Detail
2007-11-08 Added TERM indoleamine 2,3-dioxygenase activity

Definition/synonyms

Timestamp Action Category Detail
2011-09-16 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate as the reaction catalyzed may be D-tryptophan + O2 = N-formyl-D-kynurenine, or L-tryptophan + O2 = N-formyl-L-kynurenine.
2011-09-16 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
2011-09-04 Deleted DEFINITION Catalysis of the reactions: tryptophan + O2 = N-formylkynurenine; D-tryptophan + O2 = N-formyl-D-kynurenine; and L-tryptophan + O2 = N-formyl-L-kynurenine.
2011-09-04 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate as the reaction catalyzed may be D-tryptophan + O2 = N-formyl-D-kynurenine, or L-tryptophan + O2 = N-formyl-L-kynurenine.
2010-09-15 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2010-09-15 Added DEFINITION Catalysis of the reactions: tryptophan + O2 = N-formylkynurenine; D-tryptophan + O2 = N-formyl-D-kynurenine; and L-tryptophan + O2 = N-formyl-L-kynurenine.
2008-05-13 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2007-11-27 Added DEFINITION Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
2007-11-08 Added SYNONYM D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
2007-11-08 Added SYNONYM IDO
2007-11-08 Added SYNONYM tryptophan pyrrolase activity

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:RXN-8665
2009-05-21 Added XREF MetaCyc:RXN-8664
2007-11-08 Added XREF EC:1.13.11.52
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