spacer

GO:0033596 TSC1-TSC2 complex

Term Information

ID GO:0033596
Name TSC1-TSC2 complex
Ontology Cellular Component
Definition A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
PMID:10585443 PMID:17121544 PMID:9580671
GONUTS GO:0033596 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact tuberous sclerosis complex
exact tuberin-hamartin complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR003913

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033596:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0033596. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0033596 based on the entire annotation set Co-occurrence statistics for GO:0033596 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-01-24 Added DEFINITION A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2013-01-24 Deleted DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-05-13 Added DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-01-27 Updated DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-01-07 Added SYNONYM tuberous sclerosis complex
2007-10-25 Added DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation.
2007-08-12 Added SYNONYM tuberin-hamartin complex
2007-08-12 Added TERM TSC1-TSC2 complex

Term

Timestamp Action Category Detail
2007-08-12 Added TERM TSC1-TSC2 complex

Definition/synonyms

Timestamp Action Category Detail
2013-01-24 Added DEFINITION A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2013-01-24 Deleted DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-05-13 Added DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-01-27 Updated DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2008-01-07 Added SYNONYM tuberous sclerosis complex
2007-10-25 Added DEFINITION A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation.
2007-08-12 Added SYNONYM tuberin-hamartin complex

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
11ms