spacer

GO:0033209 tumor necrosis factor-mediated signaling pathway

Term Information

ID GO:0033209
Name tumor necrosis factor-mediated signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GONUTS GO:0033209 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related adipocytokine signaling pathway
narrow tumor necrosis factor alpha-mediated signaling pathway
narrow TNF-alpha-mediated signaling pathway
exact tumor necrosis factor-mediated signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR011172
InterPro IPR020419
InterPro IPR027128
InterPro IPR027133

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033209:
Relationship To GO:0033209 Child Term Child Term Name
Positively regulates GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
Part of GO:0005031 tumor necrosis factor-activated receptor activity
Negatively regulates GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
Regulates GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
Is a GO:0071847 TNFSF11-mediated signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0033209. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0033209 based on the entire annotation set Co-occurrence statistics for GO:0033209 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2011-06-24 Added DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2011-06-24 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2011-06-24 Added SYNONYM TNF-alpha-mediated signaling pathway
2011-06-24 Deleted SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2011-06-24 Deleted SYNONYM TNF-alpha-mediated signaling pathway
2011-06-24 Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2011-01-30 Added RELATION is a GO:0071356 (cellular response to tumor necrosis factor)
2009-03-15 Added SYNONYM tumor necrosis factor-mediated signalling pathway
2008-05-13 Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2008-05-12 Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2008-04-01 Updated RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
2007-08-09 Added SYNONYM TNF-alpha-mediated signaling pathway
2007-08-09 Added SYNONYM adipocytokine signaling pathway
2007-08-09 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-08-09 Deleted SYNONYM TNF-alpha-mediated signaling pathway
2007-08-09 Deleted SYNONYM adipocytokine signaling pathway
2007-08-09 Deleted SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-05-27 Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2007-05-18 Added TERM tumor necrosis factor-mediated signaling pathway
2007-05-18 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-05-18 Added SYNONYM adipocytokine signaling pathway
2007-05-18 Added SYNONYM TNF-alpha-mediated signaling pathway

Term

Timestamp Action Category Detail
2007-05-18 Added TERM tumor necrosis factor-mediated signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2011-06-24 Added DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2011-06-24 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2011-06-24 Added SYNONYM TNF-alpha-mediated signaling pathway
2011-06-24 Deleted SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2011-06-24 Deleted SYNONYM TNF-alpha-mediated signaling pathway
2011-06-24 Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2009-03-15 Added SYNONYM tumor necrosis factor-mediated signalling pathway
2008-05-13 Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2008-05-12 Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2007-08-09 Added SYNONYM TNF-alpha-mediated signaling pathway
2007-08-09 Added SYNONYM adipocytokine signaling pathway
2007-08-09 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-08-09 Deleted SYNONYM TNF-alpha-mediated signaling pathway
2007-08-09 Deleted SYNONYM adipocytokine signaling pathway
2007-08-09 Deleted SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-05-27 Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2007-05-18 Added SYNONYM tumor necrosis factor alpha-mediated signaling pathway
2007-05-18 Added SYNONYM adipocytokine signaling pathway
2007-05-18 Added SYNONYM TNF-alpha-mediated signaling pathway

Relationships

Timestamp Action Category Detail
2011-01-30 Added RELATION is a GO:0071356 (cellular response to tumor necrosis factor)
2008-04-01 Updated RELATION is a GO:0019221 (cytokine-mediated signaling pathway)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
16ms