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GO:0033173 calcineurin-NFAT signaling cascade

Term Information

ID GO:0033173
Name calcineurin-NFAT signaling cascade
Ontology Biological Process
Definition Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
PMID:12975316 PMID:15928679
GONUTS GO:0033173 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related calcineurin-NFAT signaling pathway
related calcineurin-NFAT signalling pathway

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Ontology Development Project
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033173:
Relationship To GO:0033173 Child Term Child Term Name
Regulates GO:0070884 regulation of calcineurin-NFAT signaling cascade
Negatively regulates GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
Positively regulates GO:0070886 positive regulation of calcineurin-NFAT signaling cascade

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0033173. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0033173 based on the entire annotation set Co-occurrence statistics for GO:0033173 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-14 Added SYNONYM calcineurin-NFAT signaling pathway
2012-01-14 Deleted SYNONYM calcineurin-NFAT signalling pathway
2012-01-14 Added SYNONYM calcineurin-NFAT signalling pathway
2012-01-14 Deleted DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2012-01-14 Added DEFINITION Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
2012-01-14 Updated TERM calcineurin-NFAT signaling cascade
2010-04-21 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-05-13 Added DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2008-05-12 Deleted DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2008-04-11 Deleted SYNONYM calcineurin-NFAT signalling pathway
2008-04-11 Added SYNONYM calcineurin-NFAT signalling pathway
2008-04-01 Updated RELATION is a GO:0048016 (inositol phosphate-mediated signaling)
2008-04-01 Updated RELATION is a GO:0019722 (calcium-mediated signaling)
2007-08-09 Added SYNONYM calcineurin-NFAT signalling pathway
2007-08-09 Deleted SYNONYM calcineurin-NFAT signalling pathway
2007-04-28 Added DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2007-04-28 Added TERM calcineurin-NFAT signaling pathway
2007-04-28 Added SYNONYM calcineurin-NFAT signalling pathway

Term

Timestamp Action Category Detail
2012-01-14 Updated TERM calcineurin-NFAT signaling cascade
2007-04-28 Added TERM calcineurin-NFAT signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-01-14 Added SYNONYM calcineurin-NFAT signaling pathway
2012-01-14 Deleted SYNONYM calcineurin-NFAT signalling pathway
2012-01-14 Added SYNONYM calcineurin-NFAT signalling pathway
2012-01-14 Deleted DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2012-01-14 Added DEFINITION Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
2008-05-13 Added DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2008-05-12 Deleted DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2008-04-11 Deleted SYNONYM calcineurin-NFAT signalling pathway
2008-04-11 Added SYNONYM calcineurin-NFAT signalling pathway
2007-08-09 Added SYNONYM calcineurin-NFAT signalling pathway
2007-08-09 Deleted SYNONYM calcineurin-NFAT signalling pathway
2007-04-28 Added DEFINITION A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin.
2007-04-28 Added SYNONYM calcineurin-NFAT signalling pathway

Relationships

Timestamp Action Category Detail
2010-04-21 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-04-01 Updated RELATION is a GO:0048016 (inositol phosphate-mediated signaling)
2008-04-01 Updated RELATION is a GO:0019722 (calcium-mediated signaling)
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