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GO:0031639 plasminogen activation

Term Information

ID GO:0031639
Name plasminogen activation
Ontology Biological Process
Definition The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
PMID:9548733
GONUTS GO:0031639 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact cleavage of plasminogen to plasmin

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_chembl310

Cross-references

Database ID
InterPro IPR004093
InterPro IPR008124
InterPro IPR026280
InterPro IPR034811
InterPro IPR034814

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031639:
Relationship To GO:0031639 Child Term Child Term Name
Is a GO:0044542 plasminogen activation in other organism
Regulates GO:0010755 regulation of plasminogen activation
Positively regulates GO:0010756 positive regulation of plasminogen activation
Negatively regulates GO:0010757 negative regulation of plasminogen activation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031639. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031639 based on the entire annotation set Co-occurrence statistics for GO:0031639 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2010-12-17 Deleted DEFINITION The process whereby inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-12-17 Added DEFINITION The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-04-01 Deleted DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2010-04-01 Added DEFINITION The process whereby inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-01-31 Added SYNONYM cleavage of plasminogen to plasmin
2008-05-13 Added DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2008-05-12 Deleted DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2008-04-01 Updated RELATION is a GO:0031638 (zymogen activation)
2005-10-08 Added DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2005-10-08 Added TERM plasminogen activation

Term

Timestamp Action Category Detail
2005-10-08 Added TERM plasminogen activation

Definition/synonyms

Timestamp Action Category Detail
2010-12-17 Deleted DEFINITION The process whereby inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-12-17 Added DEFINITION The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-04-01 Deleted DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2010-04-01 Added DEFINITION The process whereby inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2010-01-31 Added SYNONYM cleavage of plasminogen to plasmin
2008-05-13 Added DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2008-05-12 Deleted DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.
2005-10-08 Added DEFINITION The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0031638 (zymogen activation)

Other

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
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