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GO:0031623 receptor internalization

Term Information

ID GO:0031623
Name receptor internalization
Ontology Biological Process
Definition A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
PMID:15006537 PMID:19643732
GONUTS GO:0031623 Wiki Page

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031623:
Relationship To GO:0031623 Child Term Child Term Name
Is a GO:0002031 G-protein coupled receptor internalization
Regulates GO:0002090 regulation of receptor internalization
Negatively regulates GO:0002091 negative regulation of receptor internalization
Positively regulates GO:0002092 positive regulation of receptor internalization
Is a GO:2000286 receptor internalization involved in canonical Wnt signaling pathway
Is a GO:0036300 B cell receptor internalization
Is a GO:0038009 regulation of signal transduction by receptor internalization
Is a GO:0038016 insulin receptor internalization
Is a GO:0038017 Wnt receptor internalization

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031623. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031623 based on the entire annotation set Co-occurrence statistics for GO:0031623 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044763 (single-organism cellular process)
2013-11-28 Added RELATION is a GO:0044710 (single-organism metabolic process)
2012-12-23 Added RELATION is a GO:0044765 (single-organism transport)
2011-06-26 Added DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2011-06-26 Deleted DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation; receptors are subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation. Receptor internalization serves as a mechanism to downregulate receptor signaling.
2010-11-14 Added DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation; receptors are subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation. Receptor internalization serves as a mechanism to downregulate receptor signaling.
2010-11-14 Deleted DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2009-10-30 Deleted RELATION is a GO:0044260 (cellular macromolecule metabolic process)
2009-06-25 Added RELATION is a GO:0044260 (cellular macromolecule metabolic process)
2008-05-13 Added DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2008-05-12 Deleted DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2008-04-01 Updated RELATION is a GO:0043112 (receptor metabolic process)
2008-04-01 Updated RELATION is a GO:0006898 (receptor-mediated endocytosis)
2005-10-03 Added DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2005-10-03 Added TERM receptor internalization

Term

Timestamp Action Category Detail
2005-10-03 Added TERM receptor internalization

Definition/synonyms

Timestamp Action Category Detail
2011-06-26 Added DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2011-06-26 Deleted DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation; receptors are subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation. Receptor internalization serves as a mechanism to downregulate receptor signaling.
2010-11-14 Added DEFINITION A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation; receptors are subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation. Receptor internalization serves as a mechanism to downregulate receptor signaling.
2010-11-14 Deleted DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2008-05-13 Added DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2008-05-12 Deleted DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.
2005-10-03 Added DEFINITION The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling.

Relationships

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044763 (single-organism cellular process)
2013-11-28 Added RELATION is a GO:0044710 (single-organism metabolic process)
2012-12-23 Added RELATION is a GO:0044765 (single-organism transport)
2009-10-30 Deleted RELATION is a GO:0044260 (cellular macromolecule metabolic process)
2009-06-25 Added RELATION is a GO:0044260 (cellular macromolecule metabolic process)
2008-04-01 Updated RELATION is a GO:0043112 (receptor metabolic process)
2008-04-01 Updated RELATION is a GO:0006898 (receptor-mediated endocytosis)
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