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GO:0031594 neuromuscular junction

Term Information

ID GO:0031594
Name neuromuscular junction
Ontology Cellular Component
Definition The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
Comment In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
GONUTS GO:0031594 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related NMJ
related motor endplate

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000365 GO:0045202 synapse only_in_taxon 33208 Metazoa
More information on taxon constraints in GO is available here

Cross-Ontology Relations

Relation Other Ontology ID Term
overlaps CL CL:0000100 motor neuron
overlaps CL CL:0000187 muscle cell

Cross-references

Database ID
NIF_Subcellular sao1124888485
Wikipedia Neuromuscular_junction

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031594:
Relationship To GO:0031594 Child Term Child Term Name
Is a GO:0098520 excitatory neuromuscular junction
Is a GO:0098521 inhibitory neuromuscular junction
Is a GO:0098523 neuromuscular junction of myotube
Is a GO:0098527 neuromuscular junction of somatic muscle

Protein Annotation

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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031594. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031594 based on the entire annotation set Co-occurrence statistics for GO:0031594 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-04-06 Added SYNONYM NMJ
2013-10-17 Deleted DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2013-10-17 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2013-02-08 Added SYNONYM motor endplate
2010-02-04 Added XREF NIF_Subcellular:sao1124888485
2009-02-08 Added XREF Wikipedia:Neuromuscular_junction
2008-05-13 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2008-05-12 Deleted DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2008-04-01 Updated RELATION is a GO:0045202 (synapse)
2005-09-29 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2005-09-28 Added TERM neuromuscular junction

Term

Timestamp Action Category Detail
2005-09-28 Added TERM neuromuscular junction

Definition/synonyms

Timestamp Action Category Detail
2014-04-06 Added SYNONYM NMJ
2013-10-17 Deleted DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2013-10-17 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2013-02-08 Added SYNONYM motor endplate
2008-05-13 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2008-05-12 Deleted DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.
2005-09-29 Added DEFINITION The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0045202 (synapse)

Cross-references

Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao1124888485
2009-02-08 Added XREF Wikipedia:Neuromuscular_junction
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