spacer

GO:0031586 negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Term Information

ID GO:0031586
Name negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
GONUTS GO:0031586 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related negative regulation of IP3 receptor activity
exact down regulation of IP3 receptor activity
exact downregulation of IP3 receptor activity
narrow inhibition of IP3 receptor activity
exact down-regulation of IP3 receptor activity
exact negative regulation of inositol 1,4,5-trisphosphate receptor activity

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031586:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031586. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031586 based on the entire annotation set Co-occurrence statistics for GO:0031586 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-06-19 Added RELATION is a GO:1901020 (negative regulation of calcium ion transmembrane transporter activity)
2011-12-16 Added RELATION is a GO:2001258 (negative regulation of cation channel activity)
2011-12-16 Deleted RELATION is a GO:0032413 (negative regulation of ion transmembrane transporter activity)
2011-07-10 Added RELATION is a GO:0032413 (negative regulation of ion transmembrane transporter activity)
2011-06-29 Updated TERM negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
2011-06-29 Added SYNONYM negative regulation of inositol 1,4,5-trisphosphate receptor activity
2011-06-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2011-06-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
2011-06-29 Added RELATION negatively regulates GO:0005220 (inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
2011-06-29 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-12-05 Added RELATION is a GO:2000272 (negative regulation of receptor activity)
2010-12-05 Deleted RELATION is a GO:0044092 (negative regulation of molecular function)
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2010-06-15 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-06-14 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-06-09 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2010-06-08 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-06-08 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2009-06-11 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2009-05-11 Added RELATION is a GO:0044092 (negative regulation of molecular function)
2009-02-25 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2009-02-25 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2009-02-22 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2009-02-22 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2008-04-01 Updated RELATION is a GO:0031585 (regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
2007-10-12 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2007-10-12 Added SYNONYM negative regulation of IP3 receptor activity
2007-08-09 Added SYNONYM down regulation of IP3 receptor activity
2007-08-09 Added SYNONYM down-regulation of IP3 receptor activity
2007-08-09 Added SYNONYM downregulation of IP3 receptor activity
2007-08-09 Added SYNONYM inhibition of IP3 receptor activity
2007-08-09 Deleted SYNONYM inhibition of IP3 receptor activity
2007-08-09 Deleted SYNONYM down regulation of IP3 receptor activity
2007-08-09 Deleted SYNONYM down-regulation of IP3 receptor activity
2007-08-09 Deleted SYNONYM downregulation of IP3 receptor activity
2007-02-23 Added SYNONYM down regulation of IP3 receptor activity
2007-02-23 Added SYNONYM down-regulation of IP3 receptor activity
2007-02-23 Added SYNONYM downregulation of IP3 receptor activity
2007-02-23 Added SYNONYM inhibition of IP3 receptor activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of the activity of the IP3 receptor.
2005-09-23 Added DEFINITION Any process that stops, prevents or reduces the rate of the activity of the IP3 receptor.
2005-09-22 Added TERM negative regulation of IP3 receptor activity

Term

Timestamp Action Category Detail
2011-06-29 Updated TERM negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
2010-06-09 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2010-06-08 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2009-06-11 Updated TERM negative regulation of inositol-1,4,5-trisphosphate receptor activity
2009-02-25 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2009-02-22 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2007-10-12 Updated TERM negative regulation of inositol-1,4,5-triphosphate receptor activity
2005-09-22 Added TERM negative regulation of IP3 receptor activity

Definition/synonyms

Timestamp Action Category Detail
2011-06-29 Added SYNONYM negative regulation of inositol 1,4,5-trisphosphate receptor activity
2011-06-29 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2011-06-29 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2007-10-12 Added SYNONYM negative regulation of IP3 receptor activity
2007-08-09 Added SYNONYM down regulation of IP3 receptor activity
2007-08-09 Added SYNONYM down-regulation of IP3 receptor activity
2007-08-09 Added SYNONYM downregulation of IP3 receptor activity
2007-08-09 Added SYNONYM inhibition of IP3 receptor activity
2007-08-09 Deleted SYNONYM inhibition of IP3 receptor activity
2007-08-09 Deleted SYNONYM down regulation of IP3 receptor activity
2007-08-09 Deleted SYNONYM down-regulation of IP3 receptor activity
2007-08-09 Deleted SYNONYM downregulation of IP3 receptor activity
2007-02-23 Added SYNONYM down regulation of IP3 receptor activity
2007-02-23 Added SYNONYM down-regulation of IP3 receptor activity
2007-02-23 Added SYNONYM downregulation of IP3 receptor activity
2007-02-23 Added SYNONYM inhibition of IP3 receptor activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of the activity of the IP3 receptor.
2005-09-23 Added DEFINITION Any process that stops, prevents or reduces the rate of the activity of the IP3 receptor.

Relationships

Timestamp Action Category Detail
2012-06-19 Added RELATION is a GO:1901020 (negative regulation of calcium ion transmembrane transporter activity)
2011-12-16 Added RELATION is a GO:2001258 (negative regulation of cation channel activity)
2011-12-16 Deleted RELATION is a GO:0032413 (negative regulation of ion transmembrane transporter activity)
2011-07-10 Added RELATION is a GO:0032413 (negative regulation of ion transmembrane transporter activity)
2011-06-29 Added RELATION negatively regulates GO:0005220 (inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
2011-06-29 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2011-01-16 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2011-01-16 Deleted RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-12-05 Added RELATION is a GO:2000272 (negative regulation of receptor activity)
2010-12-05 Deleted RELATION is a GO:0044092 (negative regulation of molecular function)
2010-06-15 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-06-14 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-06-08 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2010-04-21 Added RELATION is a GO:0035467 (negative regulation of signaling pathway)
2010-04-21 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2009-05-11 Added RELATION is a GO:0044092 (negative regulation of molecular function)
2009-02-25 Deleted RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2009-02-22 Added RELATION negatively regulates GO:0008095 (inositol-1,4,5-trisphosphate receptor activity)
2008-04-01 Updated RELATION is a GO:0031585 (regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
17ms