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GO:0031427 response to methotrexate

Term Information

ID GO:0031427
Name response to methotrexate
Ontology Biological Process
Definition Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
GONUTS GO:0031427 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Response to guidelinesLink

Cross-Ontology Relations

Relation Other Ontology ID Term
has_input CHEBI CHEBI:44185 methotrexate

Cross-references

Database ID
UniProtKB-KW Methotrexate resistance

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031427:
Relationship To GO:0031427 Child Term Child Term Name
Is a GO:0071414 cellular response to methotrexate

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031427. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031427 based on the entire annotation set Co-occurrence statistics for GO:0031427 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-02-17 Added RELATION is a GO:0001101 (response to acid chemical)
2012-12-15 Added RELATION is a GO:1901700 (response to oxygen-containing compound)
2012-11-02 Added RELATION is a GO:0010243 (response to organonitrogen compound)
2011-05-08 Deleted DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2011-05-08 Added DEFINITION Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2008-05-13 Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2008-05-12 Deleted DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2008-04-01 Updated RELATION is a GO:0014070 (response to organic cyclic compound)
2005-09-20 Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2005-09-15 Updated DEFINITION A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perception of, or exposure to, methotrexate, 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2005-05-20 Added TERM response to methotrexate
2005-05-20 Added DEFINITION A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to methotrexate, 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.

Term

Timestamp Action Category Detail
2005-05-20 Added TERM response to methotrexate

Definition/synonyms

Timestamp Action Category Detail
2011-05-08 Deleted DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2011-05-08 Added DEFINITION Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2008-05-13 Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2008-05-12 Deleted DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2005-09-20 Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2005-09-15 Updated DEFINITION A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perception of, or exposure to, methotrexate, 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
2005-05-20 Added DEFINITION A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to methotrexate, 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.

Relationships

Timestamp Action Category Detail
2014-02-17 Added RELATION is a GO:0001101 (response to acid chemical)
2012-12-15 Added RELATION is a GO:1901700 (response to oxygen-containing compound)
2012-11-02 Added RELATION is a GO:0010243 (response to organonitrogen compound)
2008-04-01 Updated RELATION is a GO:0014070 (response to organic cyclic compound)
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