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GO:0031264 death-inducing signaling complex

Term Information

ID GO:0031264
Name death-inducing signaling complex
Ontology Cellular Component
Definition A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
PMID:12628743 PMID:12655293 PMID:8521815
Comment Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
GONUTS GO:0031264 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DISC protein complex
exact death receptor-induced signaling complex
exact death-inducing signalling complex
exact DISC
exact death receptor-induced signalling complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir462

Cross-references

Database ID
Wikipedia Death-inducing_signaling_complex

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031264:
Relationship To GO:0031264 Child Term Child Term Name
Is a GO:0031265 CD95 death-inducing signaling complex
Is a GO:0031266 TRAIL death-inducing signaling complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Taxon
Date
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Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0031264. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0031264 based on the entire annotation set Co-occurrence statistics for GO:0031264 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-04 Deleted DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2013-12-04 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
2013-04-18 Updated SLIM goslim_pir
2012-03-29 Added SYNONYM death receptor-induced signaling complex
2012-03-29 Added SYNONYM death receptor-induced signalling complex
2012-03-29 Added SYNONYM DISC protein complex
2009-02-08 Added XREF Wikipedia:Death-inducing_signaling_complex
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2008-05-12 Deleted DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044459 (plasma membrane part)
2007-08-09 Added SYNONYM DISC
2007-08-09 Added SYNONYM death-inducing signalling complex
2007-08-09 Deleted SYNONYM DISC
2007-08-09 Deleted SYNONYM death-inducing signalling complex
2005-03-06 Added TERM death-inducing signaling complex
2005-03-06 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2005-03-06 Added SYNONYM DISC
2005-03-06 Added SYNONYM death-inducing signalling complex

Term

Timestamp Action Category Detail
2005-03-06 Added TERM death-inducing signaling complex

Definition/synonyms

Timestamp Action Category Detail
2013-12-04 Deleted DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2013-12-04 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
2012-03-29 Added SYNONYM death receptor-induced signaling complex
2012-03-29 Added SYNONYM death receptor-induced signalling complex
2012-03-29 Added SYNONYM DISC protein complex
2008-05-13 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2008-05-12 Deleted DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2007-08-09 Added SYNONYM DISC
2007-08-09 Added SYNONYM death-inducing signalling complex
2007-08-09 Deleted SYNONYM DISC
2007-08-09 Deleted SYNONYM death-inducing signalling complex
2005-03-06 Added DEFINITION A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.
2005-03-06 Added SYNONYM DISC
2005-03-06 Added SYNONYM death-inducing signalling complex

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044459 (plasma membrane part)

Cross-references

Timestamp Action Category Detail
2009-02-08 Added XREF Wikipedia:Death-inducing_signaling_complex

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2008-06-09 Added SLIM goslim_pir
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