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GO:0030968 endoplasmic reticulum unfolded protein response

Term Information

ID GO:0030968
Name endoplasmic reticulum unfolded protein response
Ontology Biological Process
Definition The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
PMID:12042763
Comment Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
GONUTS GO:0030968 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related SREBP-mediated signalling pathway
exact erUPR
exact ER unfolded protein response

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030968:
Relationship To GO:0030968 Child Term Child Term Name
Part of GO:0006987 activation of signaling protein activity involved in unfolded protein response
Part of GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
Part of GO:0030969 UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
Regulates GO:1900101 regulation of endoplasmic reticulum unfolded protein response
Negatively regulates GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
Positively regulates GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030968. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030968 based on the entire annotation set Co-occurrence statistics for GO:0030968 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-10-02 Deleted SYNONYM ER stress response
2008-10-02 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
2008-07-31 Added RELATION is a GO:0034620 (cellular response to unfolded protein)
2008-07-31 Deleted RELATION is a GO:0006986 (response to unfolded protein)
2008-06-16 Deleted SYNONYM UPR
2008-06-16 Added SYNONYM ER unfolded protein response
2008-06-16 Added SYNONYM erUPR
2008-06-16 Updated TERM endoplasmic reticulum unfolded protein response
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2008-04-01 Updated RELATION is a GO:0006986 (response to unfolded protein)
2008-04-01 Updated RELATION is a GO:0006984 (ER-nucleus signaling pathway)
2007-08-09 Added SYNONYM ER stress response
2007-08-09 Added SYNONYM SREBP-mediated signalling pathway
2007-08-09 Added SYNONYM UPR
2007-08-09 Deleted SYNONYM SREBP-mediated signalling pathway
2007-08-09 Deleted SYNONYM ER stress response
2007-08-09 Deleted SYNONYM UPR
2007-05-13 Added SYNONYM SREBP-mediated signalling pathway
2004-07-24 Updated DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2004-07-22 Added TERM unfolded protein response
2004-07-22 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of trancription and translation.
2004-07-22 Added SYNONYM ER stress response
2004-07-22 Added SYNONYM UPR

Term

Timestamp Action Category Detail
2008-06-16 Updated TERM endoplasmic reticulum unfolded protein response
2004-07-22 Added TERM unfolded protein response

Definition/synonyms

Timestamp Action Category Detail
2008-10-02 Deleted SYNONYM ER stress response
2008-06-16 Deleted SYNONYM UPR
2008-06-16 Added SYNONYM ER unfolded protein response
2008-06-16 Added SYNONYM erUPR
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2007-08-09 Added SYNONYM ER stress response
2007-08-09 Added SYNONYM SREBP-mediated signalling pathway
2007-08-09 Added SYNONYM UPR
2007-08-09 Deleted SYNONYM SREBP-mediated signalling pathway
2007-08-09 Deleted SYNONYM ER stress response
2007-08-09 Deleted SYNONYM UPR
2007-05-13 Added SYNONYM SREBP-mediated signalling pathway
2004-07-24 Updated DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2004-07-22 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of trancription and translation.
2004-07-22 Added SYNONYM ER stress response
2004-07-22 Added SYNONYM UPR

Relationships

Timestamp Action Category Detail
2008-10-02 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
2008-07-31 Added RELATION is a GO:0034620 (cellular response to unfolded protein)
2008-07-31 Deleted RELATION is a GO:0006986 (response to unfolded protein)
2008-04-01 Updated RELATION is a GO:0006986 (response to unfolded protein)
2008-04-01 Updated RELATION is a GO:0006984 (ER-nucleus signaling pathway)
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