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GO:0032933 SREBP signaling pathway

Term Information

ID GO:0032933
Name SREBP signaling pathway
Ontology Biological Process
Definition A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
PMID:12923525 PMID:22017871
Secondary IDs GO:0006994 GO:0030967 GO:0035104
GONUTS GO:0032933 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response
exact positive regulation of sterol regulatory element binding protein target gene transcription
exact sterol depletion response, SREBP target gene transcriptional activation
narrow stimulation of sterol regulatory element binding protein target gene transcription
exact up regulation of sterol regulatory element binding protein target gene transcription
exact SREBP target gene transcriptional activation
broad sterol regulatory element binding protein target gene transcriptional activation
related SREBP-mediated signaling pathway
exact SREBP signalling
exact sterol response element binding protein signaling pathway
narrow activation of sterol regulatory element binding protein target gene transcription
exact ER-nuclear sterol response pathway
narrow positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway
exact upregulation of sterol regulatory element binding protein target gene transcription
narrow positive regulation of transcription via sterol regulatory element binding
exact ER to nucleus sterol response pathway
exact up-regulation of sterol regulatory element binding protein target gene transcription
exact endoplasmic reticulum to nucleus sterol response pathway
exact endoplasmic reticulum-nuclear sterol response pathway
exact SREBP-mediated signalling pathway

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription processesLink

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR030225

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0032933:
Relationship To GO:0032933 Child Term Child Term Name
Part of GO:0035103 sterol regulatory element binding protein cleavage
Part of GO:0035105 sterol regulatory element binding protein import into nucleus
Regulates GO:2000638 regulation of SREBP signaling pathway
Negatively regulates GO:2000639 negative regulation of SREBP signaling pathway
Positively regulates GO:2000640 positive regulation of SREBP signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0032933. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0032933 based on the entire annotation set Co-occurrence statistics for GO:0032933 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0035104 (positive regulation of transcription via sterol regulatory element binding)
2012-10-17 Added SECONDARY GO:0030967 (ER-nuclear sterol response pathway)
2012-10-17 Added SECONDARY GO:0006994 (positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway)
2012-10-17 Added RELATION is a GO:0071501 (cellular response to sterol depletion)
2012-10-17 Added SYNONYM up regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM SREBP target gene transcriptional activation
2012-10-17 Added SYNONYM sterol regulatory element binding protein target gene transcriptional activation
2012-10-17 Added SYNONYM positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway
2012-10-17 Added SYNONYM ER-nuclear sterol response pathway
2012-10-17 Added SYNONYM activation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response
2012-10-17 Added SYNONYM positive regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM sterol depletion response, SREBP target gene transcriptional activation
2012-10-17 Added SYNONYM stimulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM endoplasmic reticulum to nucleus sterol response pathway
2012-10-17 Added SYNONYM endoplasmic reticulum-nuclear sterol response pathway
2012-10-17 Added SYNONYM up-regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM ER to nucleus sterol response pathway
2012-10-17 Added SYNONYM positive regulation of transcription via sterol regulatory element binding
2012-10-17 Added SYNONYM upregulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-10-17 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-08-24 Added RELATION is a GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
2012-08-24 Deleted RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2012-08-24 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in regulation of transcription of target genes.
2012-08-24 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-07-22 Updated TERM SREBP signaling pathway
2012-07-22 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2012-07-22 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in regulation of transcription of target genes.
2012-07-22 Added SYNONYM SREBP-mediated signaling pathway
2012-07-22 Added SYNONYM SREBP signalling
2012-07-22 Added SYNONYM sterol response element binding protein signaling pathway
2012-07-22 Added RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2008-05-13 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2008-05-12 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2008-04-01 Updated RELATION is a GO:0006984 (ER-nucleus signaling pathway)
2007-08-09 Added SYNONYM SREBP-mediated signalling pathway
2007-08-09 Deleted SYNONYM SREBP-mediated signalling pathway
2007-05-13 Added SYNONYM SREBP-mediated signalling pathway
2007-02-23 Added TERM SREBP-mediated signaling pathway
2007-02-23 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.

Term

Timestamp Action Category Detail
2012-07-22 Updated TERM SREBP signaling pathway
2007-02-23 Added TERM SREBP-mediated signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-10-17 Added SYNONYM up regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM SREBP target gene transcriptional activation
2012-10-17 Added SYNONYM sterol regulatory element binding protein target gene transcriptional activation
2012-10-17 Added SYNONYM positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway
2012-10-17 Added SYNONYM ER-nuclear sterol response pathway
2012-10-17 Added SYNONYM activation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response
2012-10-17 Added SYNONYM positive regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM sterol depletion response, SREBP target gene transcriptional activation
2012-10-17 Added SYNONYM stimulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM endoplasmic reticulum to nucleus sterol response pathway
2012-10-17 Added SYNONYM endoplasmic reticulum-nuclear sterol response pathway
2012-10-17 Added SYNONYM up-regulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Added SYNONYM ER to nucleus sterol response pathway
2012-10-17 Added SYNONYM positive regulation of transcription via sterol regulatory element binding
2012-10-17 Added SYNONYM upregulation of sterol regulatory element binding protein target gene transcription
2012-10-17 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-10-17 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-08-24 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in regulation of transcription of target genes.
2012-08-24 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
2012-07-22 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2012-07-22 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids (or in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in regulation of transcription of target genes.
2012-07-22 Added SYNONYM SREBP-mediated signaling pathway
2012-07-22 Added SYNONYM SREBP signalling
2012-07-22 Added SYNONYM sterol response element binding protein signaling pathway
2008-05-13 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2008-05-12 Deleted DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.
2007-08-09 Added SYNONYM SREBP-mediated signalling pathway
2007-08-09 Deleted SYNONYM SREBP-mediated signalling pathway
2007-05-13 Added SYNONYM SREBP-mediated signalling pathway
2007-02-23 Added DEFINITION A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP.

Relationships

Timestamp Action Category Detail
2012-10-17 Added RELATION is a GO:0071501 (cellular response to sterol depletion)
2012-08-24 Added RELATION is a GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
2012-08-24 Deleted RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2012-07-22 Added RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2008-04-01 Updated RELATION is a GO:0006984 (ER-nucleus signaling pathway)

Other

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0035104 (positive regulation of transcription via sterol regulatory element binding)
2012-10-17 Added SECONDARY GO:0030967 (ER-nuclear sterol response pathway)
2012-10-17 Added SECONDARY GO:0006994 (positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway)
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