spacer

GO:0030877 beta-catenin destruction complex

Term Information

ID GO:0030877
Name beta-catenin destruction complex
Ontology Cellular Component
Definition A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
PMID:14600025
Comment Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Secondary IDs GO:0034742 GO:0034747
GONUTS GO:0030877 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact beta-catenin degradation complex
exact Axin-APC-beta-catenin-GSK3B complex
narrow 23S APC complex
exact APC-Axin-1-beta-catenin complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030877:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030877. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030877 based on the entire annotation set Co-occurrence statistics for GO:0030877 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-29 Added SECONDARY GO:0034747 (Axin-APC-beta-catenin-GSK3B complex)
2012-10-29 Added SECONDARY GO:0034742 (APC-Axin-1-beta-catenin complex)
2012-10-29 Added SYNONYM Axin-APC-beta-catenin-GSK3B complex
2012-10-29 Added SYNONYM 23S APC complex
2012-10-29 Added SYNONYM APC-Axin-1-beta-catenin complex
2008-05-13 Added DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2008-05-12 Deleted DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2008-04-01 Updated RELATION is a GO:0044444 (cytoplasmic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM beta-catenin degradation complex
2007-08-09 Deleted SYNONYM beta-catenin degradation complex
2004-04-19 Added SYNONYM beta-catenin degradation complex
2004-04-16 Deleted SYNONYM beta-catenin degradation complex
2004-02-06 Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2004-01-29 Added SYNONYM beta-catenin degradation complex
2003-11-30 Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2003-11-22 Added DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2003-11-22 Added TERM beta-catenin destruction complex

Term

Timestamp Action Category Detail
2003-11-22 Added TERM beta-catenin destruction complex

Definition/synonyms

Timestamp Action Category Detail
2012-10-29 Added SYNONYM Axin-APC-beta-catenin-GSK3B complex
2012-10-29 Added SYNONYM 23S APC complex
2012-10-29 Added SYNONYM APC-Axin-1-beta-catenin complex
2008-05-13 Added DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2008-05-12 Deleted DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2007-08-09 Added SYNONYM beta-catenin degradation complex
2007-08-09 Deleted SYNONYM beta-catenin degradation complex
2004-04-19 Added SYNONYM beta-catenin degradation complex
2004-04-16 Deleted SYNONYM beta-catenin degradation complex
2004-02-06 Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2004-01-29 Added SYNONYM beta-catenin degradation complex
2003-11-30 Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2003-11-22 Added DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0044444 (cytoplasmic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)

Other

Timestamp Action Category Detail
2012-10-29 Added SECONDARY GO:0034747 (Axin-APC-beta-catenin-GSK3B complex)
2012-10-29 Added SECONDARY GO:0034742 (APC-Axin-1-beta-catenin complex)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms