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GO:0030870 Mre11 complex

Term Information

ID GO:0030870
Name Mre11 complex
Ontology Cellular Component
Definition Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
PMID:11988766 PMID:17674145
GONUTS GO:0030870 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact RAD50-MRE11-NBN complex
exact MRX complex
exact Rad50-Rad32-Nbs1 complex
exact Rad50 complex
exact RMX complex
exact MRN complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct mre11_yeast Mre11 complex

Cross-references

Database ID
InterPro IPR004584

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030870:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030870. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030870 based on the entire annotation set Co-occurrence statistics for GO:0030870 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-06-01 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-06-01 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2011-03-31 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2011-03-31 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2009-03-23 Added SYNONYM RAD50-MRE11-NBN complex
2008-05-13 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2008-05-12 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM MRN complex
2007-08-09 Added SYNONYM MRX complex
2007-08-09 Added SYNONYM RMX complex
2007-08-09 Added SYNONYM Rad50 complex
2007-08-09 Added SYNONYM Rad50-Rad32-Nbs1 complex
2007-08-09 Deleted SYNONYM MRN complex
2007-08-09 Deleted SYNONYM MRX complex
2007-08-09 Deleted SYNONYM RMX complex
2007-08-09 Deleted SYNONYM Rad50 complex
2007-08-09 Deleted SYNONYM Rad50-Rad32-Nbs1 complex
2005-10-02 Added SYNONYM Rad50 complex
2005-10-02 Added SYNONYM Rad50-Rad32-Nbs1 complex
2005-03-26 Added SYNONYM MRX complex
2005-03-26 Added SYNONYM RMX complex
2004-04-19 Added SYNONYM MRN complex
2004-04-16 Deleted SYNONYM MRN complex
2003-11-25 Added SYNONYM MRN complex
2003-11-20 Added TERM Mre11 complex
2003-11-20 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.

Term

Timestamp Action Category Detail
2003-11-20 Added TERM Mre11 complex

Definition/synonyms

Timestamp Action Category Detail
2012-06-01 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-06-01 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2011-03-31 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2011-03-31 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2009-03-23 Added SYNONYM RAD50-MRE11-NBN complex
2008-05-13 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2008-05-12 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2007-08-09 Added SYNONYM MRN complex
2007-08-09 Added SYNONYM MRX complex
2007-08-09 Added SYNONYM RMX complex
2007-08-09 Added SYNONYM Rad50 complex
2007-08-09 Added SYNONYM Rad50-Rad32-Nbs1 complex
2007-08-09 Deleted SYNONYM MRN complex
2007-08-09 Deleted SYNONYM MRX complex
2007-08-09 Deleted SYNONYM RMX complex
2007-08-09 Deleted SYNONYM Rad50 complex
2007-08-09 Deleted SYNONYM Rad50-Rad32-Nbs1 complex
2005-10-02 Added SYNONYM Rad50 complex
2005-10-02 Added SYNONYM Rad50-Rad32-Nbs1 complex
2005-03-26 Added SYNONYM MRX complex
2005-03-26 Added SYNONYM RMX complex
2004-04-19 Added SYNONYM MRN complex
2004-04-16 Deleted SYNONYM MRN complex
2003-11-25 Added SYNONYM MRN complex
2003-11-20 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
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