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GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway

Term Information

ID GO:0030845
Name phospholipase C-inhibiting G-protein coupled receptor signaling pathway
Ontology Biological Process
Definition A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
PMID:8280098
Comment This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition.
GONUTS GO:0030845 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact GPCR signaling pathway coupled to inhibition of phospholipase C activity
exact PLC-inhibiting GPCR signaling pathway
related phospholipase C inhibition
exact G-protein-coupled inhibitory pathway of phospholipase C
exact GPCR signaling pathway via inhibition of PLC
narrow inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030845:
Relationship To GO:0030845 Child Term Child Term Name
Has part GO:1900275 negative regulation of phospholipase C activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030845. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030845 based on the entire annotation set Co-occurrence statistics for GO:0030845 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-05-27 Added RELATION is a GO:0007186 (G-protein coupled receptor signaling pathway)
2012-05-27 Deleted RELATION negatively regulates GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2012-05-27 Deleted RELATION is a GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
2012-05-27 Deleted RELATION is a GO:0010519 (negative regulation of phospholipase activity)
2012-05-27 Added SYNONYM GPCR signaling pathway coupled to inhibition of phospholipase C activity
2012-05-27 Added SYNONYM GPCR signaling pathway via inhibition of PLC
2012-05-27 Added SYNONYM G-protein-coupled inhibitory pathway of phospholipase C
2012-05-27 Added SYNONYM phospholipase C inhibition
2012-05-27 Added SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2012-05-27 Added SYNONYM PLC-inhibiting GPCR signaling pathway
2012-05-27 Deleted SYNONYM phospholipase C inhibition
2012-05-27 Deleted SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2012-05-27 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to a signal.
2012-05-27 Added DEFINITION A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
2012-05-27 Updated TERM phospholipase C-inhibiting G-protein coupled receptor signaling pathway
2011-01-30 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-11-17 Added SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2010-05-27 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2009-04-29 Added RELATION is a GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
2009-04-29 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to a signal.
2009-04-29 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2009-04-29 Updated TERM inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway
2009-02-25 Updated TERM inhibition of phospholipase C activity
2009-02-22 Updated TERM inhibition of phospholipase C activity
2009-01-31 Added RELATION is a GO:0010519 (negative regulation of phospholipase activity)
2009-01-31 Added RELATION negatively regulates GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2009-01-31 Deleted RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2009-01-31 Deleted RELATION part of GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2008-05-13 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2008-05-12 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2008-04-01 Updated RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2008-04-01 Updated RELATION part of GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2008-02-29 Added SYNONYM phospholipase C inhibition
2008-02-29 Updated TERM inhibition of phospholipase C activity
2003-09-03 Updated DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2003-09-02 Added TERM phospholipase C inhibition
2003-09-02 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.

Term

Timestamp Action Category Detail
2012-05-27 Updated TERM phospholipase C-inhibiting G-protein coupled receptor signaling pathway
2009-04-29 Updated TERM inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway
2009-02-25 Updated TERM inhibition of phospholipase C activity
2009-02-22 Updated TERM inhibition of phospholipase C activity
2008-02-29 Updated TERM inhibition of phospholipase C activity
2003-09-02 Added TERM phospholipase C inhibition

Definition/synonyms

Timestamp Action Category Detail
2012-05-27 Added SYNONYM GPCR signaling pathway coupled to inhibition of phospholipase C activity
2012-05-27 Added SYNONYM GPCR signaling pathway via inhibition of PLC
2012-05-27 Added SYNONYM G-protein-coupled inhibitory pathway of phospholipase C
2012-05-27 Added SYNONYM phospholipase C inhibition
2012-05-27 Added SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2012-05-27 Added SYNONYM PLC-inhibiting GPCR signaling pathway
2012-05-27 Deleted SYNONYM phospholipase C inhibition
2012-05-27 Deleted SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2012-05-27 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to a signal.
2012-05-27 Added DEFINITION A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
2010-11-17 Added SYNONYM inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
2009-04-29 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to a signal.
2009-04-29 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2008-05-13 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2008-05-12 Deleted DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2008-02-29 Added SYNONYM phospholipase C inhibition
2003-09-03 Updated DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.
2003-09-02 Added DEFINITION A signaling pathway that results in preventing the activation of phospholipase C in response to the signal.

Relationships

Timestamp Action Category Detail
2012-05-27 Added RELATION is a GO:0007186 (G-protein coupled receptor signaling pathway)
2012-05-27 Deleted RELATION negatively regulates GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2012-05-27 Deleted RELATION is a GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
2012-05-27 Deleted RELATION is a GO:0010519 (negative regulation of phospholipase activity)
2011-01-30 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2010-05-27 Added RELATION is a GO:0009968 (negative regulation of signal transduction)
2009-04-29 Added RELATION is a GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
2009-01-31 Added RELATION is a GO:0010519 (negative regulation of phospholipase activity)
2009-01-31 Added RELATION negatively regulates GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2009-01-31 Deleted RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2009-01-31 Deleted RELATION part of GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2008-04-01 Updated RELATION part of GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
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