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GO:0030433 ER-associated ubiquitin-dependent protein catabolic process

Term Information

ID GO:0030433
Name ER-associated ubiquitin-dependent protein catabolic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.
PMID:14607247 PMID:19520858
Comment See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
GONUTS GO:0030433 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact ER-associated protein catabolism
exact ER-associated protein catabolic process
exact endoplasmic reticulum-associated protein catabolism
exact proteasomal protein catabolism of ER proteins
exact ER-associated protein degradation
exact endoplasmic reticulum-associated protein catabolic process
broad ERAD
exact ER-associated protein breakdown

Cross-references

Database ID
InterPro IPR017247
InterPro IPR032832
InterPro IPR033294

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030433:
Relationship To GO:0030433 Child Term Child Term Name
Is a GO:0071712 ER-associated misfolded protein catabolic process
Regulates GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process
Negatively regulates GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process
Positively regulates GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030433. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030433 based on the entire annotation set Co-occurrence statistics for GO:0030433 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-13 Added SYNONYM proteasomal protein catabolism of ER proteins
2015-05-19 Deleted SYNONYM ERAD
2015-05-19 Added SYNONYM ERAD
2015-05-19 Added RELATION part of GO:0036503 (ERAD pathway)
2013-10-31 Added SYNONYM ER-associated protein catabolic process
2013-10-31 Updated TERM ER-associated ubiquitin-dependent protein catabolic process
2010-03-13 Deleted RELATION is a GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
2010-03-13 Deleted RELATION is a GO:0071218 (cellular response to misfolded protein)
2010-03-13 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2010-03-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.
2010-02-13 Added RELATION is a GO:0071218 (cellular response to misfolded protein)
2010-02-13 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2010-02-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2008-04-01 Updated RELATION is a GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
2008-04-01 Updated RELATION is a GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
2007-08-09 Added SYNONYM ER-associated protein breakdown
2007-08-09 Added SYNONYM ER-associated protein catabolism
2007-08-09 Added SYNONYM ER-associated protein degradation
2007-08-09 Added SYNONYM ERAD
2007-08-09 Added SYNONYM endoplasmic reticulum-associated protein catabolic process
2007-08-09 Added SYNONYM endoplasmic reticulum-associated protein catabolism
2007-08-09 Deleted SYNONYM ER-associated protein catabolism
2007-08-09 Deleted SYNONYM endoplasmic reticulum-associated protein catabolic process
2007-08-09 Deleted SYNONYM ER-associated protein breakdown
2007-08-09 Deleted SYNONYM ER-associated protein degradation
2007-08-09 Deleted SYNONYM ERAD
2007-08-09 Deleted SYNONYM endoplasmic reticulum-associated protein catabolism
2007-01-15 Updated TERM ER-associated protein catabolic process
2007-01-15 Added SYNONYM ER-associated protein catabolism
2007-01-15 Added SYNONYM endoplasmic reticulum-associated protein catabolic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2005-08-10 Added SYNONYM ER-associated protein breakdown
2004-11-09 Added SYNONYM endoplasmic reticulum-associated protein catabolism
2004-07-26 Added SYNONYM ER-associated protein degradation
2004-07-22 Updated DEFINITION The breakdown into simpler components of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2004-04-28 Added DEFINITION The breakdown into simpler components of proteins in the endoplasmic reticulum.
2004-04-19 Added SYNONYM ERAD
2004-04-16 Deleted SYNONYM ERAD
2003-03-19 Deleted SYNONYM ER degradation
2002-08-15 Updated TERM ER-associated protein catabolism
2001-11-23 Added SYNONYM ER degradation
2001-11-23 Added SYNONYM ERAD
2001-11-23 Added TERM ER-associated protein degradation

Term

Timestamp Action Category Detail
2013-10-31 Updated TERM ER-associated ubiquitin-dependent protein catabolic process
2007-01-15 Updated TERM ER-associated protein catabolic process
2002-08-15 Updated TERM ER-associated protein catabolism
2001-11-23 Added TERM ER-associated protein degradation

Definition/synonyms

Timestamp Action Category Detail
2015-06-13 Added SYNONYM proteasomal protein catabolism of ER proteins
2015-05-19 Deleted SYNONYM ERAD
2015-05-19 Added SYNONYM ERAD
2013-10-31 Added SYNONYM ER-associated protein catabolic process
2010-03-13 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2010-03-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.
2010-02-13 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2010-02-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2007-08-09 Added SYNONYM ER-associated protein breakdown
2007-08-09 Added SYNONYM ER-associated protein catabolism
2007-08-09 Added SYNONYM ER-associated protein degradation
2007-08-09 Added SYNONYM ERAD
2007-08-09 Added SYNONYM endoplasmic reticulum-associated protein catabolic process
2007-08-09 Added SYNONYM endoplasmic reticulum-associated protein catabolism
2007-08-09 Deleted SYNONYM ER-associated protein catabolism
2007-08-09 Deleted SYNONYM endoplasmic reticulum-associated protein catabolic process
2007-08-09 Deleted SYNONYM ER-associated protein breakdown
2007-08-09 Deleted SYNONYM ER-associated protein degradation
2007-08-09 Deleted SYNONYM ERAD
2007-08-09 Deleted SYNONYM endoplasmic reticulum-associated protein catabolism
2007-01-15 Added SYNONYM ER-associated protein catabolism
2007-01-15 Added SYNONYM endoplasmic reticulum-associated protein catabolic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2005-08-10 Added SYNONYM ER-associated protein breakdown
2004-11-09 Added SYNONYM endoplasmic reticulum-associated protein catabolism
2004-07-26 Added SYNONYM ER-associated protein degradation
2004-07-22 Updated DEFINITION The breakdown into simpler components of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2004-04-28 Added DEFINITION The breakdown into simpler components of proteins in the endoplasmic reticulum.
2004-04-19 Added SYNONYM ERAD
2004-04-16 Deleted SYNONYM ERAD
2003-03-19 Deleted SYNONYM ER degradation
2001-11-23 Added SYNONYM ER degradation
2001-11-23 Added SYNONYM ERAD

Relationships

Timestamp Action Category Detail
2015-05-19 Added RELATION part of GO:0036503 (ERAD pathway)
2010-03-13 Deleted RELATION is a GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
2010-03-13 Deleted RELATION is a GO:0071218 (cellular response to misfolded protein)
2010-02-13 Added RELATION is a GO:0071218 (cellular response to misfolded protein)
2008-04-01 Updated RELATION is a GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
2008-04-01 Updated RELATION is a GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
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